PMID: 8970816Sep 15, 1996Paper

Pharmacokinetics of kanamycin in the developing rat

Hearing Research
C M HenleyR D Brown

Abstract

The developing rat is hypersensitive to aminoglycoside ototoxicity during the period of anatomical and functional development of the cochlea. Toxicity is expressed only after a few days of treatment when kanamycin is given during the most sensitive period for production of ototoxicity (postnatal days 11-20). In contrast, when the drug is administered after the 20th postnatal day, the same dose and duration of treatment do not produce an ototoxic effect. Only after prolonged treatment (e.g., > or = 20 days) is there an observed effect. We characterized the pharmacokinetics of kanamycin in the serum of 12- and 25-day-old rats and observed a greater than 2.5-fold increase in elimination half-life in the 12- versus 25-day-old rat. The longer duration half-life of kanamycin in younger rats may explain the hypersensitivity of immature mammals to aminoglycoside ototoxicity.

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Citations

Jun 2, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tamer ErdemErcument Olmez
Jul 18, 2002·Hearing Research·Murat Cem MimanErcument Olmez
Mar 19, 1999·Hearing Research·C D MillsC M Henley
Aug 21, 2003·Auris, Nasus, Larynx·Ahmet KizilayMurat Cem Miman

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