Pharmacokinetics of Levofloxacin in Children Treated for Exposure to Drug-Resistant Tuberculosis

Antimicrobial Agents and Chemotherapy
Amyn A MalikCourtney M Yuen

Abstract

Levofloxacin is used to treat and prevent drug-resistant tuberculosis in children. We assessed levofloxacin serum drug concentrations in 24 children aged 2 to 10 years who received levofloxacin-based tuberculosis preventive therapy in Karachi, Pakistan. Only 9 children (37.5%) achieved adequate drug exposure. Target serum drug concentration was met in 4 (26.7%) of 15 children dosed consistently with World Health Organization recommendations and 4 (80.0%) of 5 who received higher-than-recommended doses. Levofloxacin dosing recommendations may require reevaluation.

References

Sep 26, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James A SeddonH Simon Schaaf
May 23, 2014·Drugs·Abdullah Alsultan, Charles A Peloquin
Sep 10, 2014·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S BamrahS Mase
Mar 13, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·Nils E Billo
Mar 24, 2017·The European Respiratory Journal·Dennis FalzonKarin Weyer
Nov 15, 2017·Antimicrobial Agents and Chemotherapy·Paolo DentiAnneke C Hesseling
Mar 30, 2018·The Pediatric Infectious Disease Journal·Miti A Shah, Ira Shah
Jul 18, 2018·Antimicrobial Agents and Chemotherapy·Charles A PeloquinC Robert Horsburgh

❮ Previous
Next ❯

Citations

Jan 19, 2019·The European Respiratory Journal·Samiksha GhimireJan-Willem C Alffenaar
Jan 12, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Kyle John Wilby, Farhat Naz Hussain

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Related Papers

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
F AmanullahM C Becerra
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
W W YewC H Chau
The Annals of Pharmacotherapy
Charles A PeloquinM D Iseman
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Afsheen AyazRumina Hasan
Pakistan Journal of Health
A H SAEED
© 2022 Meta ULC. All rights reserved