Pharmacokinetics of Levofloxacin in Multidrug- and Extensively Drug-Resistant Tuberculosis Patients

Antimicrobial Agents and Chemotherapy
Natasha Van't Boveneind-VrubleuskayaJan-Willem C Alffenaar

Abstract

Pharmacodynamics are especially important in the treatment of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB). The free area under the concentration time curve in relation to MIC (fAUC/MIC) is the most relevant pharmacokinetic (PK)-pharmacodynamic (PD) parameter for predicting the efficacy of levofloxacin (LFX). The objective of our study was to assess LFX PK variability in M/XDR-TB patients and its potential consequence for fAUC/MIC ratios. Patients with pulmonary M/XDR-TB received LFX as part of the treatment regimen at a dose of 15 mg/kg administered once daily. Blood samples obtained at steady state before and 1, 2, 3, 4, 7, and 12 h after drug administration were measured by validated liquid chromatography-tandem mass spectrometry. The MIC values of LFX were determined by the agar dilution method on Middlebrook 7H10 and the MGIT960 system. Twenty patients with a mean age of 31 years (interquartile range [IQR] = 27 to 35 years) were enrolled in this study. The median AUC0-24 was 98.8 mg/h/liter (IQR = 84.8 to 159.6 mg/h/liter). The MIC median value for LFX was 0.5 mg/liter with a range of 0.25 to 2.0 mg/liter, and the median fAUC0-24/MIC ratio was 109.5 (IQR = 48.5 to 399.4). In 4 of the 20 patients, the v...Continue Reading

References

Jun 1, 1995·Antimicrobial Agents and Chemotherapy·B JIJ Grosset
Feb 1, 1997·Clinical Pharmacokinetics·D N Fish, A T Chow
Apr 3, 2001·International Journal of Antimicrobial Agents·J C RodríguezG Royo
May 1, 2001·Clinical Pharmacokinetics·A AminimanizaniR Jelliffe
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Noman SiddiqiSeyed E Hasnain
Aug 7, 2002·Clinical Pharmacokinetics·Eugénie Bergogne-Bérézin
Sep 25, 2003·Antimicrobial Agents and Chemotherapy·Nicolas VezirisNacer Lounis
Jul 14, 2006·International Journal of Antimicrobial Agents·John E ConteElisabeth Zurlinden
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Charles A PeloquinJohn L Johnson
Sep 13, 2008·American Journal of Respiratory and Critical Care Medicine·Reynaldo DietzeJohn L Johnson
Apr 20, 2011·Antimicrobial Agents and Chemotherapy·Guy E ThwaitesPaul G Ambrose
Aug 13, 2011·Current Pharmaceutical Design·D H VuD R A Uges
Oct 19, 2011·The European Respiratory Journal·Alena SkrahinaMatteo Zignol
Oct 25, 2011·The Journal of Infectious Diseases·Shashikant SrivastavaTawanda Gumbo
May 9, 2012·Antimicrobial Agents and Chemotherapy·Emmanuel ChigutsaCarl M J Kirkpatrick
Jul 7, 2012·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN Center For Drug Evaluation And Research Food And Drug Administration
Feb 12, 2013·Bulletin of the World Health Organization·Alena SkrahinaMatteo Zignol
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf
Apr 19, 2013·American Journal of Respiratory and Critical Care Medicine·Zahoor AhmadEric L Nuermberger
Jul 3, 2013·European Journal of Public Health·Marieke J van der WerfTeymur Noori
Aug 10, 2013·American Journal of Respiratory and Critical Care Medicine·Won-Jung KohJae-Joon Yim
Oct 9, 2013·Antimicrobial Agents and Chemotherapy·Jongseok LeeMoses L Joloba
May 23, 2014·Drugs·Abdullah Alsultan, Charles A Peloquin
Jul 25, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Peter CegielskiUNKNOWN Global Preserving Effective TB Treatment Study (PETTS) Investigators
Dec 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jan-Willem C AlffenaarRob E Aarnoutse
Mar 18, 2015·Antimicrobial Agents and Chemotherapy·Russell R KempkerHenry M Blumberg
Apr 15, 2015·Antimicrobial Agents and Chemotherapy·Abdullah AlsultanCharles A Peloquin
Aug 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tawanda GumboDebra Hanna
Aug 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tawanda GumboEric Nuermberger
Sep 1, 2012·International Journal of Mycobacteriology·Senia Rosales-KlintzSven E Hoffner
May 28, 2016·The Journal of Antimicrobial Chemotherapy·Samiksha GhimireJan-Willem C Alffenaar

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Citations

Oct 31, 2018·Antimicrobial Agents and Chemotherapy·Simone H J van den ElsenJan-Willem C Alffenaar
Jan 19, 2019·The European Respiratory Journal·Samiksha GhimireJan-Willem C Alffenaar
Dec 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lina Davies ForsmanJudith Bruchfeld
Jan 12, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Kyle John Wilby, Farhat Naz Hussain
Oct 13, 2020·Expert Opinion on Drug Metabolism & Toxicology·Anne-Grete MärtsonCharles A Peloquin
Jun 6, 2020·Tuberculosis·Carlijn H C LitjensLindsey H M Te Brake

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