Pharmacokinetics of lidocaine and its major metabolite- monoethylglycinexylidide (MEGX) in rabbits with experimental common bile duct obstruction

European Journal of Drug Metabolism and Pharmacokinetics
J WójcickiU Gołdyn

Abstract

The aim of this study was to evaluate, using an experimental model, the effect of obstructive cholestasis on the pharmacokinetics of lidocaine and the formation rate of its major metabolite- monoethylglycinexylidide (MEGX)-in rabbits. The investigation was carried out on 20 rabbits, randomly divided into two groups: a control one sham-operated and an experimental one-animals with biliary duct ligation. The measurements, i.e. laboratory and pharmacodynamic tests, as well as pharmacokinetic assays were performed prior to the operation as well as 10-12 days after the bile duct ligation. At the end stage of the study, livers were examined macro- and microscopically and biochemical analysis of the liver microsomes were performed. Lidocaine was given intravenously, as a bolus of 6 mg/kg. Blood for pharmacokinetic assay was sampled within 6 h following the drug administration, and MEGX concentration was evaluated 15 min after lidocaine had been administered. The immunofluorescence polarization method was employed for determination of lidocaine and MEGX concentrations. The one-compartment open model was used for calculations.

References

Nov 21, 1975·European Journal of Clinical Investigation·N CarulliM Gallo
Nov 1, 1989·Clinical Pharmacology and Therapeutics·M J BargetziU A Meyer
Dec 1, 1987·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M OellerichM Scheruhn
Oct 4, 1974·European Journal of Clinical Pharmacology·J Elfström, S Lindgren
Nov 1, 1982·The Journal of Pharmacy and Pharmacology·R J FruncilloG J DiGregorio
Nov 1, 1982·Journal of Pharmaceutical Sciences·P J Basseches, G J DiGregorio
Sep 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·M SchinellaM Caputo

❮ Previous
Next ❯

Citations

Jul 29, 2011·European Journal of Clinical Pharmacology·Antonio RuggieroRiccardo Riccardi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.