Pharmacokinetics of liposomal-encapsulated and un-encapsulated vincristine after injection of liposomal vincristine sulfate in beagle dogs

Cancer Chemotherapy and Pharmacology
Jie ZhongYueming Ma

Abstract

Vincristine sulfate (VCR) is a potent and widely used anti-tumor drug. Encapsulating VCR with liposomes improves its therapeutic index. However, there is little known about the pharmacokinetic features of un-encapsulated VCR (UE-VCR) and encapsulated VCR (E-VCR). Two groups of beagle dogs were intravenously administered a single 0.07 mg/kg dose of VCR liposomal injection (L-VCR) and VCR ordinary injection (I-VCR), respectively. The concentrations of UE-VCR, E-VCR and total VCR (T-VCR) were determined by separating UE-VCR and E-VCR, using solid-phase extraction and validated liquid chromatography-tandem mass spectrometry-based methods. Pharmacokinetic parameters were calculated, using the compartment model. The pharmacokinetic parameters of L-VCR and I-VCR were compared using a Student's t test. After intravenous injection of L-VCR, the pharmacokinetic parameters of E-VCR were similar to those of T-VCR. The concentrations of UE-VCR were very low, and its AUC (0-72h) was only 2.5 % that of T-VCR. Compared with I-VCR, plasma AUC of E-VCR increased, with significantly extended distribution t 1/2 and reduced distribution volume of the peripheral department. C2 min and AUC 0-1h of plasma UE-VCR decreased, with a similar elimination t...Continue Reading

References

Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sheela A AbrahamMarcel B Bally
Aug 24, 2004·Cancer Chemotherapy and Pharmacology·Klaus MrossChristine E Swenson
Nov 26, 2009·Indian Journal of Pediatrics·Sunil GomberDevender Chhonker
Oct 7, 2011·Annals of Hematology·Larry C BaconYasser R Abou Mourad
May 16, 2012·Hematology Reports·Christian Gisselbrecht
Dec 6, 2012·Cancer Chemotherapy and Pharmacology·Jeffrey A Silverman, Steven R Deitcher

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Citations

Oct 16, 2015·Veterinary and Comparative Oncology·R S LewisK L Mealey
Aug 26, 2014·Journal of Liposome Research·Apostolos PapachristosCostas Demetzos
Apr 12, 2015·The Veterinary Journal·Tzu-Yin LinYuanpei Li
Dec 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna Zabielska-Koczywąs, Roman Lechowski
Oct 14, 2017·Veterinary and Comparative Oncology·B BørresenA T Kristensen
Feb 27, 2015·The Journal of Veterinary Medical Science·Hajime AsadaHajime Tsujimoto
Feb 5, 2015·The Journal of Veterinary Medical Science·Supannika HantrakulSaranya Poapolathep
Jan 10, 2021·Journal of Veterinary Internal Medicine·Kathryn A LaQuagliaKatharine F Lunn
Jan 14, 2021·Journal of Veterinary Pharmacology and Therapeutics·Salah Uddin AhmadJiyu Zhang
May 27, 2015·Chemical Reviews·Bhushan S PattniVladimir P Torchilin

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