PMID: 12776810Jun 5, 2003Paper

Pharmacokinetics of lithium in healthy volunteers after exposure to high altitude

International Journal of Clinical Pharmacology and Therapeutics
A ArancibiaW A Ritschel

Abstract

Exposure of the human body to high altitude causes a number of physiological changes. In previous studies, we observed that these changes may alter the pharmacokinetics of drugs. The number of erythrocytes/mm3 increases both, after acute exposure to high altitude (HA), i.e. within 12 - 24 h after reaching high altitude (H), as well as in chronic exposure (HC) (> 10 months) to H. Also binding of drugs to biologic material may change with exposure to HA and/or HC. Since lithium is transported into and out of erythrocytes and binds strongly to erythrocytes, but is not plasma protein-bound, we selected this drug as candidate for the present study. Lithium carbonate 300 mg were administered orally to young healthy volunteers. One group residing at low altitude (Santiago, Chile, 600 m, group L), these same volunteers after 15 hours of exposure to high altitude (4,360 m, group HA), and volunteers living at high altitude for at least 10 months (group HC). We found a significant increase of both hematocrit and red blood cell count (RBC) after exposure to H, both, acute or chronic. Elimination half-life increased 64.1% in group HA and 111.4% in group HC in comparison to group L. We also found an increase in volume of distribution: + 18.9...Continue Reading

Citations

Feb 5, 2005·European Journal of Clinical Pharmacology·Michael StreitWalter E Haefeli
Mar 31, 2012·European Journal of Drug Metabolism and Pharmacokinetics·Xiang-Yang LiYong-Fang Li
Jan 28, 2004·Annual Review of Psychology·Lisa A Serbin, Jennifer Karp
Aug 28, 2013·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Motonao IshikawaKuniaki Otsuka
Dec 12, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Shefali GolaAsheesh Gupta
Sep 3, 2011·Suicide & Life-threatening Behavior·Marian E BetzBenjamin Honigman
Nov 22, 2017·High Altitude Medicine & Biology·Elaine RenoBenjamin Honigman
Oct 21, 2016·Environmental Geochemistry and Health·Shahnawaz BalochMuhammad Balal Arain
Jul 26, 2019·High Altitude Medicine & Biology·Katharina HüfnerHermann Brugger
Nov 15, 2019·CNS & Neurological Disorders Drug Targets·Wen JinhuaTan Jun
Jun 23, 2011·Clinical Schizophrenia & Related Psychoses·Nancy Brahm, Christopher M Puls
Jan 8, 2020·International Journal of Environmental Research and Public Health·Jiazhou WangZhengkui Liu
Jan 30, 2021·Spatial and Spatio-temporal Epidemiology·Lorena Cecilia López SteinmetzJuan Carlos Godoy

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