Pharmacokinetics of magnesium and its effects on clinical variables following experimentally induced hypermagnesemia.

Journal of Veterinary Pharmacology and Therapeutics
Stephen A SchumacherAlicia L Bertone

Abstract

The objectives of this study were to describe pharmacokinetic and pharmacodynamic changes as a result of a single intravenous administration of magnesium sulfate (MgSO4 ) to healthy horses. MgSO4 is a magnesium salt that has been used to calm horses in equestrian competition and is difficult to regulate because magnesium is an essential constituent of all mammals. Six healthy adult female horses were administered a single intravenous dose of MgSO4 at 60 mg/kg of body weight over 5 min. Blood, urine, and cerebrospinal fluid (CSF) samples were collected, and cardiovascular parameters were monitored and echocardiograms performed at predetermined times. Noncompartmental pharmacokinetic analysis was applied to plasma concentrations of ionized magnesium (Mg2+ ). Objective data were analyzed using the Wilcoxon rank-sum test with p < .05 used as a determination for significance. Plasma concentrations of Mg2+ increased nearly fivefold, ionized calcium (Ca2+ ) decreased by nearly 10%, and the Ca2+ to Mg2+ ratio declined more than 3.5-fold and remained different than baseline until 24 hr (p < .05). Significant changes were seen with urinary fractional excretion of electrolytes, cardiovascular parameters, and echocardiographic measurements...Continue Reading

References

Aug 3, 2000·Frontiers in Bioscience : a Journal and Virtual Library·G A Quamme, C de Rouffignac
Sep 12, 2000·Current Hypertension Reports·J L Izzo, A A Taylor
Aug 24, 2001·Journal of the American Veterinary Medical Association·E Aguilera-TejeroM Rodríguez
Jun 14, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·George G Somjen
Mar 2, 2006·American Journal of Veterinary Research·Ignacio LopezEscolastico Aguilera-Tejero
Nov 23, 2007·Journal of the American Society of Nephrology : JASN·Mauro BustamanteEric Féraille
Nov 5, 2008·Pflügers Archiv : European journal of physiology·Gerardo Gamba, Peter A Friedman
Jan 13, 2009·Domestic Animal Endocrinology·K M RourkeR E Toribio
Aug 4, 2009·Journal of Veterinary Internal Medicine·C C SchwarzwaldJ D Bonagura
Nov 20, 2009·American Journal of Physiology. Renal Physiology·Daniela Riccardi, Edward M Brown
Dec 17, 2009·Best Practice & Research. Clinical Obstetrics & Gynaecology·M F M James
Mar 12, 2011·The Veterinary Clinics of North America. Equine Practice·Allison J Stewart
Nov 5, 2011·The Journal of Clinical Hypertension·Mark Houston
Mar 1, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Michael S Lord, John G T Augoustides
Nov 13, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ewout J Hoorn, Robert Zietse
Apr 5, 2013·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·Ronald E Bishop
Apr 27, 2013·Experimental & Translational Stroke Medicine·Thomas WestermaierRalf-Ingo Ernestus
Oct 8, 2013·Handbook of Clinical Neurology·Erica A Wehrwein, Michael J Joyner
Jan 17, 2014·The Lancet. Respiratory Medicine·Brian H Rowe
Dec 30, 2014·Physiological Reviews·Jeroen H F de BaaijRené J M Bindels
Feb 1, 2012·Clinical Kidney Journal·Wilhelm Jahnen-Dechent, Markus Ketteler
Nov 26, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·Q LongUNKNOWN WHO Multicountry Survey on Maternal and Newborn Health Research Network
Nov 25, 2017·Journal of Cardiothoracic and Vascular Anesthesia·Peter BiesenbachRinaldo Bellomo
Aug 8, 2018·American Journal of Veterinary Research·Ludovic TanquerelMathilde Leclere
Jan 23, 2019·Journal of Veterinary Internal Medicine·Shara A SheldonJohn E Madigan
Apr 17, 2019·Journal of Veterinary Internal Medicine·Shara A SheldonJohn E Madigan

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.