Pharmacokinetics of meropenem after intravenous, intramuscular and subcutaneous administration to cats

Journal of Feline Medicine and Surgery
G A AlbarellosM F Landoni

Abstract

The aim of the study was to describe the pharmacokinetics and predicted efficacy of meropenem after intravenous (IV), intramuscular (IM) and subcutaneous (SC) administration to cats at a single dose of 10 mg/kg. Five adult healthy cats were used. Blood samples were withdrawn at predetermined times over a 12 h period. Meropenem concentrations were determined by microbiological assay. Pharmacokinetic analyses were performed with computer software. Initial estimates were determined using the residual method and refitted by non-linear regression. The time that plasma concentrations were greater than the minimum inhibitory concentration (T >MIC) was estimated by applying bibliographic MIC values and meropenem MIC breakpoint. Maximum plasma concentrations of meropenem were 101.02 µg/ml (Cp(0), IV), 27.21 µg/ml (Cmax, IM) and 15.57 µg/ml (Cmax, SC). Bioavailability was 99.69% (IM) and 96.52 % (SC). Elimination half-lives for the IV, IM and SC administration were 1.35, 2.10 and 2.26 h, respectively. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. However, clinical trials are necessary to confi...Continue Reading

References

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Feb 24, 2009·American Journal of Veterinary Research·Reidun HeieneRobert J Gerritsen
Dec 21, 2012·Journal of Feline Medicine and Surgery·Gabriela A AlbarellosMaría F Landoni

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Citations

Jun 22, 2019·Journal of Veterinary Pharmacology and Therapeutics·Vernon C LangstonCathleen A Mochal-King

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Software Mentioned

Phoenix WinNonlin
GraphPad Prism

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