PMID: 9549642Apr 29, 1998Paper

Pharmacokinetics of metoclopramide in neonates

Journal of Clinical Pharmacology
G L KearnsJ L Blumer

Abstract

Despite its wide use as a prokinetic agent in neonates and infants with gastroesophageal reflux (GER), the pharmacokinetics of metoclopramide have not been characterized in this pediatric subpopulation. A single-dose pharmacokinetic study of oral metoclopramide (0.1 to 0.15 mg/kg) was performed in 10 fasted premature infants (weight 1.1 to 3.2 kg) ranging from 31 to 40 weeks postconceptional age. Metoclopramide was quantitated from repeated blood samples (n = 9 over 24 hours) by high-performance liquid chromatography. A one-compartment open model with first-order absorption best described the plasma concentration-time data. No correlations were observed between gestational, postnatal, or postconceptional age and any of the pharmacokinetic parameters studied. Comparison of the pharmacokinetic parameters from the study cohort and those reported previously from a similar study of older infants revealed no statistically significant differences. However, a prolonged apparent plasma clearance (Cl/F) of metoclopramide was observed in 30% of the infants studied, and the mean Cl/F and apparent steady-state volume of distribution (Vdss/F) were approximately 1.4- and 2.1-fold higher, respectively, than values reported in previous studies ...Continue Reading

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References

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Citations

Mar 24, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J-J Baudon
Mar 29, 2002·Clinics in Perinatology·Laura P James
Jun 23, 2009·The Journal of Pediatrics·Eva Wheatley, Kathleen A Kennedy
Dec 18, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Philip O Anderson, Verónica Valdés
Apr 24, 2020·Clinical and Translational Science·Shufan GeUNKNOWN Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee

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