PMID: 6980684Aug 1, 1982Paper

Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis

The British Journal of Venereal Diseases
C S EasmonS G Dawson

Abstract

The hydroxy metabolite of metronidazole was found to be more active against 21 strains of Gardnerella vaginalis than the parent compound and less affected by culture in carbon dioxide. After 400 mg oral metronidazole (Flagyl) plasma concentrations of the two agents were below the minimum inhibitory concentrations (MICs) for most G vaginalis strains tested. With 2 g metronidazole the plasma concentrations exceeded the MICs of the more sensitive strains. Even with the lower dose of metronidazole clinically useful concentration of metronidazole and its hydroxy metabolite were present in the urine. Urinary excretion of these compounds may contribute to the efficacy of metronidazole in the treatment of vaginitis associated with G vaginalis.

References

Nov 30, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·Y KatayamaJ T Williams
Jun 29, 1978·The New England Journal of Medicine·T A PheiferK K Holmes
Nov 14, 1981·British Medical Journal·S G DawsonC S Easmon
Sep 11, 1980·The New England Journal of Medicine·C A SpiegelK K Holmes

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Citations

Oct 28, 2009·Current Infectious Disease Reports·Jack D Sobel
Apr 1, 1983·The British Journal of Venereal Diseases·S TabaqchaliR N Thin
Oct 1, 1983·The British Journal of Venereal Diseases·B E SandersonM J Baldson
Jun 1, 1984·The British Journal of Venereal Diseases·F JerveE Hoftvedt
Aug 1, 1989·Genitourinary Medicine·H MoiE Tornqvist
Jan 1, 1989·The Journal of Infection·A W Sturm
Feb 14, 2015·The Journal of Infectious Diseases·Bryan T MayerJoshua T Schiffer
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna PauterBogusław Buszewski

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