PMID: 6159323Apr 1, 1980Paper

Pharmacokinetics of middle-molecular hydroxyethyl starch (HAS 200/0,5

Infusionstherapie Und Klinische Ernährung
J M Mishler

Abstract

The pharmacokinetics of middle molecular weight hydroxyethyl starch (HES; MW 200,000, Mn: 35,000, MW/Mn = 5.71, MS = 0.50) were examined in two groups of normovalaemic subjects. Subjects in group 1 (non-fasted) were administered an approximately equal dose of HES, twice as rapidly as subjects in group 2 (fasted pre- and postinjection). The intravascular half-life (IT50) of HES in groups 1 and 2 was 2.7 +/- 1.3 and 3.9 +/- 1.1 (SD), respectively. 96 h post-injection, 2% of the initially measured HES 200/0.5 concentration remained in the serum of group 1 subjects. The serum glucose level in both groups rose following dosing and remained elevated 12 h post-injection. 24 h post-injection, 66 (group 1) and 50% (group 2) of total infused HES 200/0.5 had been excreted in the urine. In group 2 subjects, the viscosity of the urine measured up to 12 h post-injection, was not significantly affected by the presence of HES 200/0.5. Immediately post-injection in group 1 subjects, the plasma volume was increased an average of 27%, returning to normal baseline values over the next 24 h. The serum alpha-amylase activity rose in group 2 subjects post-injection, concomitantly with a significant reduction in urinary excretion of this enzyme. The m...Continue Reading

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