Pharmacokinetics of minocycline in renal failure.

Antimicrobial Agents and Chemotherapy
P G WellingW A Craig

Abstract

The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in the tissue distribution of antibiotic in the body in uremia. After identical multiple oral dosage regimens serum levels of antibiotic were comparable in normal and mildly uremic subjects. There was no evidence of renal toxicity in normal or uremic subjects with the repeated dosage regimen used.

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Citations

Sep 1, 1977·Antimicrobial Agents and Chemotherapy·P G WellingP O Madsen
Nov 1, 1979·Antimicrobial Agents and Chemotherapy·J V CruesR C Moellering
Aug 14, 2010·Stroke; a Journal of Cerebral Circulation·Susan C FaganDavid C Hess
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Aug 1, 1978·Journal of Pharmaceutical Sciences·P G Welling, W A Craig
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Dec 23, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D S BurgessJ H Jorgensen
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Feb 21, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Benjamin ColtonLarry H Danziger
Nov 7, 2018·Antimicrobial Agents and Chemotherapy·Ziad TaraziDavid C Griffith
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Aug 4, 2020·SAGE Open Medical Case Reports·Kamal SharmaSupatida Tengsupakul
Mar 8, 2019·Journal of Pharmaceutical and Biomedical Analysis·Mark A J BaylissAlasdair MacGowan

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