Pharmacokinetics of mitomycin C (MMC) after intraperitoneal administration of MMC-gelatin gel and its anti-tumor effects against sarcoma-180 bearing mice

Journal of Drug Targeting
T FujitaS Muranishi

Abstract

Gelatin viscous solution containing mitomycin C (MMC) was prepared and its antitumor effects were evaluated toward sarcoma-180 (S-180) ascite tumor bearing mice. Among various gelatin concentrations, 3% and 5% gelatin solutions potentiated the antitumor effects of MMC (7.5 mg/kg) against S-180 bearing mice. A "bell-shaped" profile was observed between % release of MMC from the gelatin matrix and increased life span (ILS) %. On the other hand, in the case of 10 mg/kg dose of MMC, 7.5% and 10% gelatin solutions potentiated its antitumor effects. At both doses of 7.5 and 10 mg/kg of MMC, decrease in body weight of mice after intraperitoneal administration of MMC were suppressed by increasing the concentration of gelatin. To confirm a possible mechanism for increase in ILS % after intraperitoneal (i.p.) administration of the gelatin viscous solution containing MMC, we examined the pharmacokinetics of MMC after i.p. administration into rats. By the use of 3 % gelatin solution, mean residence time (MRT) and Tmax values were significantly prolonged, and Cmax was decreased as compared with the administration of MMC solution. These results suggested that the enhancement of antitumor effect of MMC by the gelatin viscous solution could be...Continue Reading

References

Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Nov 1, 1992·Pharmaceutical Research·L W CheongL F Wong
Jan 1, 1990·The Journal of Pharmacy and Pharmacology·Y Tabata, Y Ikada
Mar 1, 1986·Chemical & Pharmaceutical Bulletin·S MiyazakiY Morimoto
Jun 1, 1986·Cancer Treatment Reviews·V A Levin

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Citations

Nov 10, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K NishidaJ Nakamura
Oct 12, 2013·Survey of Ophthalmology·Bruno F FernandesMiguel N Burnier
Oct 2, 2012·Surgical Oncology Clinics of North America·Kurt Van der SpeetenPaul H Sugarbaker
Dec 18, 2015·Experimental Eye Research·Andre A M TorricelliSteven E Wilson
May 12, 2010·Acta Ophthalmologica·Israel KremerShmuel Levinger
Sep 1, 2004·International Journal of Pharmaceutics·Akira YamamotoShozo Muranishi
Dec 14, 2011·Cornea·Marcony R SanthiagoSteven E Wilson
Apr 25, 2006·The Journal of Craniofacial Surgery·Mohamed Al MalyanNureddin Ashammakhi
May 26, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lieselotte LemoineKurt Van der Speeten
May 22, 2010·Current Opinion in Ophthalmology·Ravindra A Shah, Steven E Wilson
Dec 24, 2011·Journal of Strength and Conditioning Research·Andréia Silveira de SouzaLuiz Fernando Martins Kruel

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