Pharmacokinetics of morphine in fish: winter flounder (Pseudopleuronectes americanus) and seawater-acclimated rainbow trout (Oncorhynchus mykiss)

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
N C NewbyE D Stevens

Abstract

We made a single intraperitoneal (IP) injection of morphine sulfate (40 mg/kg) into winter flounder and seawater acclimated rainbow trout at 10 degrees C and then followed its disposition by measuring the change in plasma morphine concentration for 100 h using a morphine specific ELISA. Disposition also was followed for 6h after a single IV injection of 7.5mg morphine sulfate in winter flounder. Plasma morphine reached a maximum within an hour post-injection IP and then decreased in a bi-exponential fashion with a rapid distribution phase followed by a slower elimination phase. The disposition was slower in flounder than in trout even though the fish were held at the same temperature. For example, plasma clearance was 76 mL h(-)(1) kg(-)(1) in the flounder but was almost twice as much in the trout (153 mL h(-)(1) kg(-)(1)) and mean residence time was 27.9h in the flounder but was 7.0 h in the trout. The present study is the first comprehensive pharmacokinetic analysis for any analgesic in an ectotherm, and our results show that: 1) significant intra-specific variation exists between fishes: and 2) the disposition of morphine in fish is approximately one order of magnitude slower than it is in mammals. These differences may be d...Continue Reading

References

Aug 1, 1990·The Journal of Pharmacy and Pharmacology·Y M el-Sayed, M M Hasan
Mar 1, 1970·Anesthesiology·G A Jansen, N M Greene
Mar 21, 2002·Journal of Veterinary Pharmacology and Therapeutics·P M TaylorM Bloomfield
Oct 1, 1958·Physics in Medicine and Biology·A C GROOM, S ROWLANDS
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Lynne U SneddonMichael J Gentle
Aug 18, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Natércia JoaquimA Kurt Gamperl
Dec 16, 2005·The AAPS Journal·Renate ReimschuesselClifford Hodsdon

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Citations

Jul 12, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jessica L WardLysa P Posner
Jun 5, 2007·American Journal of Veterinary Research·Nathalie C NewbyE Don Stevens
Sep 6, 2013·Journal of the American Veterinary Medical Association·Tracie R BakerKurt K Sladky
Mar 29, 2014·American Journal of Veterinary Research·A Michelle Wargo RubE P Scott Weber
Jan 16, 2016·Environmental Science and Pollution Research International·Damien A DevaultSara Karolak
Mar 1, 2008·Journal of Veterinary Pharmacology and Therapeutics·N C NewbyE D Stevens
Aug 24, 2012·Journal of Veterinary Pharmacology and Therapeutics·R B ZanonJ E P Cyrino
Jan 11, 2012·Journal of Veterinary Pharmacology and Therapeutics·S G JonesE D Stevens
Jun 26, 2012·The Science of the Total Environment·Raktim PalRavi Naidu

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