PMID: 18194117Jan 16, 2008Paper

Pharmacokinetics of mycophenolic acid during the early period after renal transplant

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
Fatemeh NazemianMassih Naghibi

Abstract

Mycophenolic acid, the active metabolite of mycophenolate mofetil, is administered with cyclosporine and oral steroids to prevent acute rejection after renal transplant. The aim of this study was to investigate correlations among time after transplant, subjects' demographics, and mycophenolate mofetil dosage according to body weight withmycophenolic acid pharmacokinetics during the early posttransplant period. Mycophenolic acid plasma levels of 19 patients were determined by a validated high-performance liquid chromatographic method at the steady state soon after transplant when graft function was good (glomerular filtration rate = 70 mL/min). All patients received a fixed dosage of mycophenolate mofetil (1 g b.i.d.) in combination with cyclosporine and steroids. The area under the time-concentration curve (AUC) and mycophenolic acid plasma clearance were measured for each patient. The AUC from zero to 12 hours and trough levels increased as the time after transplant increased (P < .05), but mycophenolic acid plasma clearance decreased over time (P = .02). There was a correlation between total body weight and the AUC (P = .01, r2 = -0.627) as well as between total body weight and mycophenolic acid clearance (P = .04, r2 = 0.555...Continue Reading

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