PMID: 9549665Apr 29, 1998Paper

Pharmacokinetics of mycophenolic acid in renal transplant patients with delayed graft function

Journal of Clinical Pharmacology
L M ShawK L Brayman

Abstract

The pharmacokinetics of mycophenolic acid (MPA), the immunosuppressant form of the prodrug mycophenolate mofetil (MMF), and the primary glucuronide metabolite, MPAG, were characterized in renal transplant patients with delayed graft function using random effects piecewise linear models. Eight patients were evaluated after receiving their first and subsequent daily oral doses of 1.5 g mycophenolate mofetil twice daily on study days 1 (n = 8), 7 (n = 8), 14 (n = 5), 21 (n = 2), and 28 (n = 7). The area under the concentration-time curve from zero to 12 hours (AUC0-12) for MPA, MPAG, MPA free fraction, and free MPA were analyzed in serial plasma samples using validated high-performance liquid chromatography and ultrafiltration procedures. Random effects piecewise linear models, fit by maximum likelihood methods, were applied to AUC0-12 of MPA and MPAG, MPA free fraction, AUC0-12 of free MPA, and serum creatinine concentration, the index of renal function used in this study. Two hemodialysis sessions did not lower MPA plasma concentration, although some MPAG was removed. The AUC0-12 of MPA increased as a function of time, although it was not possible to fit a statistical model to the data due to considerable among-patient variation...Continue Reading

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Citations

Mar 10, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A B JainR Venkataramanan
Dec 9, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Bronwyn AtchesonSusan E Tett
Aug 29, 1998·Clinical Biochemistry·L M ShawR G Morris
Aug 29, 1998·Clinical Biochemistry·L M ShawK L Brayman
Sep 2, 1998·Transplantation Proceedings·L M ShawK L Brayman
Apr 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Josep M GrinyóMercé Brunet
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