Pharmacokinetics of new antiepileptic drugs

Epilepsia
L Gram

Abstract

This article surveys the pharmacokinetic parameters for the new antiepileptic drugs (AEDs): felbamate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin. Compared to the pharmacokinetics of standard AEDs, these new AEDs have progressed in terms of (a) longer half-lives, permitting once- or twice-daily dosing, (b) greatly reduced potential for drug interactions, thus increasing ease of treatment, and (c) general lack of hepatic enzyme induction, which facilitates polytherapy as well as other aspects of treatment.

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Citations

Apr 29, 1998·Molecular Neurobiology·O A Petroff, D L Rothman
Jul 6, 2000·European Journal of Pharmacology·M SwiaderS J Czuczwar
May 15, 2002·Journal of Pharmaceutical and Biomedical Analysis·H LevertH Robert
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May 26, 2004·Seizure : the Journal of the British Epilepsy Association·Patricia G Hosking
Sep 3, 2009·Journal of Food Science·Leila El BassiToru Matsui

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