PMID: 702300Oct 1, 1978Paper

Pharmacokinetics of oral cephalosporins: cephradine cephalexin

Journal of Pharmaceutical Sciences
E FinkelsteinC H Nightingale

Abstract

A crossover experiment was utilized to compare the pharmacokinetics of a 1-g dose of cephalexin tablets, cephalexin capsules, or cephradine capsules in nine normal human volunteers. These antibiotics were administered as three formulations: two 500-mg capsulin every 6 hr for five doses, and one 1000-mg tablet of cephalexin every 6 hr for five doses. Pharmacokinetic parameters in the experimental groups showed no statistical differences (p greater than 0.1), indicating that these drugs are equivalent pharmacokinetically.

References

Feb 1, 1977·Antimicrobial Agents and Chemotherapy·M PfefferJ P de Menezes
Jun 8, 1973·Drug and Therapeutics Bulletin

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Citations

Apr 1, 1979·Journal of Clinical Pharmacology·M ChowC H Nightingale
Apr 1, 1992·Journal of Clinical Pharmacy and Therapeutics·M E Abdel-HamidY A Beltagy
Nov 1, 1980·Antimicrobial Agents and Chemotherapy·J B LecaillonW Vischer
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·D K SommersS M Harding
Nov 1, 1978·The Journal of Pediatrics·E R FinkelsteinC H Nightingale
Dec 1, 1987·Journal of Clinical Pharmacy and Therapeutics·N M NajibM E Abdulhameed
Feb 1, 1988·Journal of Clinical Pharmacy and Therapeutics·M S SuleimanM E Abdulhameed
Aug 1, 1988·Journal of Clinical Pharmacology·R D FaulknerB M Silber
Apr 1, 1985·Biopharmaceutics & Drug Disposition·P G WellingC A Johnson
Sep 12, 2002·Drug Metabolism and Drug Interactions·G JayasagarY Madhusudan Rao

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