Pharmacokinetics of oral chlortetracycline in nonpregnant adult ewes

Journal of Veterinary Pharmacology and Therapeutics
K WashburnS Washburn

Abstract

The objectives of this study were to determine plasma concentrations and pharmacokinetic parameters of feed-grade chlortetracycline (CTC) in sheep after oral administration of 80 or 500 mg/head daily, divided into two equal doses given at 12-h intervals for 8 days. These are the approved, and commonly used but unapproved, feed additive doses, respectively, in the United States for the prevention of ovine infectious abortion. Blood samples were collected just prior to dosing at 0, 12, 24, 72, 96, and 192 h, as well as 4, 8, 12, 24, and 36 h after the last dose, and noncompartmental pharmacokinetic analysis was performed to estimate elimination half-life and area under the plasma concentration-time curve (AUC). Mean observed maximum CTC concentrations (Cmax ) were 20.0 ng/mL (80 mg dose) and 101 ng/mL (500 mg dose). Mean apparent elimination half-life was 18 h (80 mg dose) and 20 h (500 mg dose). Although published data do not exist to estimate plasma CTC concentrations necessary for the prevention of ovine infectious abortion, concentrations reached in our study suggest that either the FDA-approved and FDA-unapproved dosages are not high enough or that the pharmacodynamic parameter relating preventive dose to pathogen minimum in...Continue Reading

References

Jun 1, 1982·Antimicrobial Agents and Chemotherapy·K VosbeckM Petignat
Jul 17, 2007·Clinical Microbiology Reviews·John Turnidge, D L Paterson
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·J B ReinboldM D Apley
Jan 11, 2011·The Veterinary Clinics of North America. Food Animal Practice·P Menzies
Apr 23, 2011·Tropical Animal Health and Production·Elisha Gootwine
Apr 2, 2013·Neuroscience Research·Seiji Tanabe

Citations

Aug 8, 2018·Journal of Veterinary Internal Medicine·Paul J PlummerDavid C Van Metre
Jan 19, 2019·Journal of Veterinary Pharmacology and Therapeutics·Evelyn E MacKayS Washburn
Sep 12, 2017·Journal of Veterinary Pharmacology and Therapeutics·K WashburnS Washburn
Feb 27, 2020·American Journal of Veterinary Research·Michael J YaegerRonald W Griffith
May 16, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Deng LiuJianhua Wang

Related Concepts

Abortion, Septic
Antibiotics
Chlortetracycline Sulfate (2: 1)
Dall Sheep
Sheep Diseases
Chlortetracycline
Plasma
Sheep
United States Food and Drug Administration
Blood Specimen

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

Journal of Veterinary Pharmacology and Therapeutics
K WashburnS Washburn
European Journal of Drug Metabolism and Pharmacokinetics
M C Nahata, K I Koranyi
Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians
Michael J AdkessonTomás Martín-Jiménez
© 2021 Meta ULC. All rights reserved