PMID: 7437241Sep 1, 1980Paper

Pharmacokinetics of oral disopyramide phosphate in patients with renal impairment

British Journal of Clinical Pharmacology
A JohnstonN A Hamer

Abstract

1 The pharmacokinetics of disopyramide were studied after the oral administration of a 300 mg dose to 11 patients with stable chronic renal impairment (creatinine clearance 2-53 ml min-1). 2 Absorption half-life and volume of distribution were similar to those seen in normal subjects. 3 Mean plasma elimination half-life in these patients was 12.7 h, which is substantially greater than that reported for normal subjects. Elimination half-life tended to increase as creatinine clearance fell, and renal clearance of disopyramide correlated significantly (r=0.814; P < 0.001) with creatinine clearance. 4 From these results, we have calculated that patients with renal impairment should be started on a dose of disopyramide 1.5 mg kg-1 thrice daily and the regimen subsequently altered according to plasma concentrations of the drug. However, further studies are needed to define the handling of the metabolites of disopyramide.

References

Aug 1, 1978·The Journal of Pharmacy and Pharmacology·K F Rhodes, J F Waterfall
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Citations

Jan 1, 1983·European Journal of Clinical Pharmacology·M CanalA Dufour
Jan 1, 1986·European Journal of Clinical Pharmacology·J BondeJ P Kampmann
Jan 1, 1983·European Journal of Drug Metabolism and Pharmacokinetics·B FrancoisM Lussignol
Jan 1, 1983·Pharmacology & Therapeutics·D M Roden, R L Woosley
Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W M BennettI Singer
Jan 1, 1989·Fundamental & Clinical Pharmacology·P CacoubC Jacobs
Apr 1, 1983·British Journal of Clinical Pharmacology·B M DavidN S Stenhouse
Mar 1, 1982·Journal of Clinical and Hospital Pharmacy·S M BrysonB Whiting
Apr 1, 1985·Journal of Clinical Pharmacology·M CanalA Baglin
Jan 15, 1988·The American Journal of Cardiology·R L Woosley, C Funck-Brentano
Oct 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·A KarimD L Azarnoff

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