PMID: 6499905Jan 1, 1984Paper

Pharmacokinetics of oral indoramin in elderly and middle-aged female volunteers

European Journal of Clinical Pharmacology
H M NorburyS J Warrington

Abstract

Indoramin was administered as a single 50 mg oral tablet to 5 elderly (aged 68-71 years) and 6 middle-aged (aged 46-55 years) healthy female volunteers. The mean half life of indoramin in elderly subjects (14.7 +/- 4.8 h, mean +/- SEM) was statistically significantly longer than that seen in middle-aged subjects (5.1 +/- 1.0 h). The mean plasma concentrations of indoramin and mean area under the plasma concentration/time curve were also greater in elderly than in middle-aged subjects, although this did not achieve statistical significance. In many elderly patients, therefore, a reduction in dosage may be required due to the apparent reduction in clearance of indoramin. However, because of the wide inter-subject variability observed in the oral pharmacokinetics of indoramin, individual titration of indoramin dosage in all patients may be desirable.

References

Jan 1, 1979·British Journal of Clinical Pharmacology·C M Castleden, C F George
Jun 1, 1976·British Journal of Clinical Pharmacology·G H DraffanC T Dollery
Jan 1, 1976·Clinical Pharmacokinetics·J CrooksI H Stevenson
Jan 1, 1983·European Journal of Clinical Pharmacology·H M NorburyS J Warrington
Dec 1, 1981·Annals of Internal Medicine·J G Ouslander
Jan 1, 1982·Current Medical Research and Opinion·G N VolansT Frost
Mar 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R A FranklinT Ward
Sep 1, 1981·British Journal of Clinical Pharmacology·P C RubinJ L Reid
Nov 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R A Franklin, D M Pierce

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Citations

Jan 1, 1988·European Journal of Clinical Pharmacology·D M PierceR A Franklin
Dec 1, 1990·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D M Pierce
May 1, 1989·Human Toxicology·S M AbramsP Turner
Mar 1, 1988·Biopharmaceutics & Drug Disposition·D M PierceR A Franklin
Jan 1, 1987·European Journal of Clinical Pharmacology·D M PierceR A Franklin

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