PMID: 833338Jan 1, 1977

Pharmacokinetics of orally administered hydroflumethiazide in man

Journal of Clinical Pharmacology
G J YakatanJ T Doluisio

Abstract

Hydroflumethiazide plasma and urine levels were measured fluorometrically following the oral administration of 100-mg doses (2 X 50 mg tablets) to each of 12 healthy, adult male subjects. The plasma level data as a function of time were fit to a one-compartment open model using a nonlinear regression digital computer program. The means of the individual apparent absorption and disposition rate apparent absorption and disposition rate constants were 0.770+/-0.46 hr(-1) (t1/2=0.9 hr) and 0.358+/-0.17 hr(-1) (t1/2=1.94 hr), respectively, with a 0.49+/-0.26 hr lag time in absorption. The same parameter estimates obtained by fitting the mean plasma concentration-time curve were 0.461+/-0.15 hr(-1), 0.357+/-0.13 hr(-1), and 0.39+/-0.09 hr for the apparent absorption and disposition rate constants and the lag time, respectively. The closeness of the parameter estimates and the lack of intravenous data preclude unequivocal assignment of the rate constants to the absorption or disposition processes. Nevertheless, the disposition of hydroflumethiazide is clearly a rapid process. The means of the individual peak plasma levels and times to peak were 0.301+/-0.94 microgram/ml and 2.12+/-0.59 hours, respectively. The mean area under the plas...Continue Reading

References

Aug 1, 1976·Journal of Pharmaceutical Sciences·R B SmithG J Yakatan
Aug 1, 1975·Journal of Pharmaceutical Sciences·W J VandenheuvelF J Wolf
Feb 1, 1969·The Journal of Pharmacy and Pharmacology·J A Hersey, R B Barzilay
Nov 1, 1974·Journal of Pharmaceutical Sciences·Y GarceauJ Hasegawa
Sep 1, 1968·Clinical Pharmacology and Therapeutics·P J TannenbaumA P Crosley
May 1, 1961·Archives of Internal Medicine·K V ANDERSONJ K AIKAWA
Mar 1, 1960·Toxicology and Applied Pharmacology·H SHEPPARDA J PLUMMER

Citations

Apr 1, 1978·Journal of Clinical Pharmacology·P J McNamaraM Gibaldi
Nov 9, 1978·European Journal of Clinical Pharmacology·O BrørsE Arnesen
Sep 1, 1979·European Journal of Clinical Pharmacology·O Brørs, S Jacobsen
Nov 1, 1986·Biopharmaceutics & Drug Disposition·P G Welling
Oct 1, 1982·Biopharmaceutics & Drug Disposition·R R BrodieL M Walmsley

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