PMID: 8604671Jan 1, 1996Paper

Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans

The American Journal of Clinical Nutrition
J ZempleniD B McCormick

Abstract

The pharmacokinetics and utilization (flavocoenzyme synthesis) of orally and intravenously administered riboflavin in healthy humans were assessed. After the determination of circadian rhythms of riboflavin concentrations in blood plasma and urine of four males and five females (control period), each of these subjects received three different oral riboflavin doses (20, 40, and 60 mg) and one intravenous bolus injection of riboflavin (11.6 mg). Vitamins were administered in a randomized, cross-over design with 2 wk between each administration. Blood plasma and urine specimens were collected repeatedly over a period of 48 h after each administration. Concentrations of flavocoenzymes and riboflavin were analyzed in blood plasma; riboflavin was assayed in urine. During the control period, a small circadian variation was observed: plasma concentrations and urinary excretion of riboflavin were low during the afternoon (P < 0.05). Pharmacokinetics were calculated using a two-compartment open model. The maximal amount of riboflavin that can be absorbed from a single dose was 27 mg per adult. Half-life of absorption was 1.1 h. First-order rate constants describing distribution and elimination of riboflavin were significantly higher afte...Continue Reading

Citations

Aug 31, 1999·The Proceedings of the Nutrition Society·H J Powers
Aug 2, 2006·Biological & Pharmaceutical Bulletin·Masayuki AkimotoKenji Sugibayashi
Jun 9, 2007·The American Journal of Clinical Nutrition·Jack R DaintyHilary J Powers
Apr 8, 2011·International Urogynecology Journal·Shavi FernandoAnna Rosamilia
Feb 19, 2013·The British Journal of Nutrition·Agnieszka Irena Mazur-BialyBarbara Plytycz
Jan 21, 2014·Cephalalgia : an International Journal of Headache·Serena L Orr, Sunita Venkateswaran
Oct 28, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Zhonghao XinChangjiang Guo
Mar 18, 2000·The Journal of Nutrition·D B McCormick
Apr 4, 2003·Journal of the American College of Nutrition·Miguel Navarro, Richard J Wood
Mar 1, 2011·Headache·Frederick R Taylor
Feb 12, 2015·Nutrition Research and Practice·Young-Nam KimYoun-Ok Cho
Nov 18, 2000·American Journal of Physiology. Cell Physiology·N YanagawaH M Said
Jul 29, 2010·Cephalalgia : an International Journal of Headache·Hope L O'Brien, Andrew D Hershey
Oct 4, 2005·European Journal of Nutrition·S E RasmussenJ C Larsen
Jul 18, 2008·American Journal of Physiology. Cell Physiology·Atsushi YonezawaKen-ichi Inui
Aug 4, 2009·The Journal of Headache and Pain·Maria CondòAntonia Parmeggiani
Oct 12, 2014·Psychopharmacology·Rae A LittlewoodKent E Hutchison
Feb 7, 2013·Current Opinion in Clinical Nutrition and Metabolic Care·Anura V KurpadIsabelle Aeberli
Jun 1, 2013·Drug Delivery and Translational Research·Mayank Shekhar Upadhyay, Kamla Pathak
Jun 15, 2016·Journal of Clinical Psychopharmacology·Aidan J HampsonSharon L Walsh
May 10, 2017·Journal of Clinical Pharmacy and Therapeutics·D F Thompson, H S Saluja
Feb 8, 2018·Food & Function·T RequenaC Peláez
Jan 27, 2019·Journal of Inherited Metabolic Disease·Shanti BalasubramaniamShamima Rahman
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Tirthankar SinhaMuayyad R Al-Ubaidi
Jun 7, 2003·The American Journal of Clinical Nutrition·Hilary J Powers
May 1, 2009·The American Journal of Clinical Nutrition·Leane HoeyJ J Strain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
J ZempleniD B McCormick
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition
J ZempleniD B McCormick
Antimicrobial Agents and Chemotherapy
E A SwabbA Sugerman
© 2021 Meta ULC. All rights reserved