PMID: 1276000Apr 1, 1976Paper

Pharmacokinetics of pancuronium in patients with normal and impaired renal function

British Journal of Anaesthesia
K McLeodM D Rawlins


Plasma concentrations of pancuronium were measured using a fluorimetric method in six patients with normal renal function and seven patients in chronic renal failure. A tow-compartment open model was used in the pharmacokinetic analysis of the data. With this model, the clearance of pancuronium was found to be reduced significantly in the patients with renal failure, and in these individuals the volume of the central (distribution) compartment was increased significantly. The clinical implications of these findings are discussed.


Aug 17, 1977·European Journal of Clinical Pharmacology·A A SomogyiE J Triggs
Jan 1, 1981·European Journal of Clinical Pharmacology·D R BevanR L Smith
Mar 1, 1982·Canadian Anaesthetists' Society Journal·F B Allen, P B Kane
Nov 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M D Sharpe
May 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E Crosby, J A Robblee
Mar 1, 1979·Canadian Anaesthetists' Society Journal·R D Miller
Jul 1, 1984·Canadian Anaesthetists' Society Journal·P H Weir, F F Chung
Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Watson, K McLeod
Jul 12, 2008·British Journal of Anaesthesia·R G Craig, J M Hunter
Nov 16, 2004·Critical Care Medicine·Jeffery S VenderMartin Nitsun
Feb 1, 1978·Anaesthesia·R K MirakhurJ R McDonald
Jul 1, 1979·Anaesthesia·D R Bevan
Oct 1, 1993·Anaesthesia·K S Khuenl-BradyJ Koller
Jan 1, 1994·Acta Anaesthesiologica Scandinavica. Supplementum·J M Hunter
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J M Elliot, J F Bion
Aug 1, 1977·British Journal of Pharmacology·R D Miller, L Roderick
Feb 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Paul M Palevsky
Nov 1, 1983·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·W M BennettI Singer
Oct 1, 2011·Current Therapeutic Research, Clinical and Experimental·Sinan GursoyCaner Mimaroglu
Dec 1, 1981·The Australian and New Zealand Journal of Surgery·J Gomez-ArnauF Avello
Sep 1, 1980·Anaesthesia·D R BevanR L Smith
Apr 17, 2015·Seminars in Dialysis·Ameet KarambelkarPaul M Palevsky
Jan 1, 1992·Journal of Anesthesia·T Nomura
Jan 15, 2009·European Journal of Anaesthesiology·Sinan GursoyCaner Mimaroglu
Mar 8, 2019·Journal of Cellular Physiology·Reza Alizadeh, Ziba A Fard
Jan 1, 1991·DICP : the Annals of Pharmacotherapy·G E LarijaniA G Jacobi
May 1, 1985·Anaesthesia and Intensive Care·J P BradleyJ P O'Connor
Nov 1, 1983·Anaesthesia and Intensive Care·A R Marsland, J P Bradley
Nov 1, 1983·Anaesthesia and Intensive Care·P J Maddern
Feb 1, 1980·Anaesthesia and Intensive Care·C A ShanksE J Triggs
Jan 1, 1978·Acta Anaesthesiologica Scandinavica·F Camu, A D'Hollander
Aug 1, 1979·Anaesthesia and Intensive Care·C A ShanksE J Triggs
Nov 1, 1983·Anaesthesia and Intensive Care·C Nancarrow, L E Mather

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