Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses

American Journal of Veterinary Research
C E UbohA O Watson

Abstract

To compare the pharmacokinetics of penicillin G and procaine in racehorses following i.m. administration of penicillin G procaine (PGP) with pharmacokinetics following i.m. administration of penicillin G potassium and procaine hydrochloride (PH). 6 healthy adult mares. Horses were treated with PGP (22,000 units of penicillin G/kg of body weight, i.m.) and with penicillin G potassium (22,000 U/kg, i.m.) and PH (1.55 mg/kg, i.m.). A minimum of 3 weeks was allowed to elapse between drug treatments. Plasma and urine penicillin G and procaine concentrations were measured by use of high-pressure liquid chromatography. Median elimination phase half-lives of penicillin G were 24.7 and 12.9 hours, respectively, after administration of PGP and penicillin G potassium. Plasma penicillin G concentration 24 hours after administration of penicillin G potassium and PH was not significantly different from concentration 24 hours after administration of PGP. Median elimination phase half-life of procaine following administration of PGP (15.6 hours) was significantly longer than value obtained after administration of penicillin G potassium and PH (1 hour). Results suggest that i.m. administration of penicillin G potassium will result in plasma pen...Continue Reading

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Citations

Feb 20, 2013·Research in Veterinary Science·Lena OlsénCarina Ingvast-Larsson
Jan 15, 2015·Journal of Veterinary Internal Medicine·D M RhodesS J Spier
Jun 14, 2017·Equine Veterinary Journal·L Y HardefeldtK E Bailey
Jun 20, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Miao LiZhoumeng Lin
Apr 25, 2018·Australian Veterinary Journal·L Y HardefeldtK E Bailey
Oct 5, 2019·Equine Veterinary Journal·M A Mercer, J L Davis

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