PMID: 590316Dec 2, 1977

Pharmacokinetics of phenobarbital in childhood

European Journal of Clinical Pharmacology
G Heimann, E Gladtke

Abstract

In 14 neonates 1-4 weeks old, 30 babies aged 1-12 months, and 7 infants of 1-5 years of age, the serum levels of phenobarbital were determined by a gas chromatographic micro-method after intravenous injection of phenobarbital 5-10 mg per kg body weight. It was possible to calculate the pharmacokinetic parameters using a two compartment open model. The distribution volumes within the individual age groups and the rate constants k12 and k21 showed no significant differences, but the elimination half-life was significantly longer in neonates (118.6+/-16.1h) than in babies (62.9+/-5.2h) or infants (68.5+/-3.2h).

References

Jan 1, 1977·European Journal of Clinical Pharmacology·H M von HattingbergG Kreuter
Feb 1, 1975·Journal of Pharmacokinetics and Biopharmaceutics·D D BreimerJ M van Rossum
May 1, 1975·Acta paediatrica Scandinavica·B Jalling
Oct 1, 1975·The Journal of Pediatrics·A Brachet-LiermainJ Aicardi
Oct 15, 1971·Klinische Wochenschrift·E Heinze, H G Kampffmeyer
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Apr 1, 1967·Journal of Pharmaceutical Sciences·J G Wagner, J I Northam
Dec 1, 1963·Epilepsia·O Svensmark, F Buchthal

Citations

May 1, 1980·European Journal of Pediatrics·H Bartels
Jul 1, 1980·European Journal of Clinical Pharmacology·G Heimann
Jan 1, 1982·Canadian Anaesthetists' Society Journal·D KadarA W Conn
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Dec 5, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·D J TouwM M van Weissenbruch
Dec 21, 2012·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Renée A ShellhaasVarsha Bhatt-Mehta
Feb 1, 1986·Australian Paediatric Journal·N Buchanan
Feb 1, 1980·Archives of Disease in Childhood·G W Rylance, T A Moreland
Sep 13, 2003·British Journal of Clinical Pharmacology·Gilbert O KokwaroCharles R J C Newton
Jul 1, 1990·The Journal of Emergency Medicine·Y Amitai, Y Degani
Aug 1, 1980·The Journal of Pediatrics·P D WalsonD Perrier
May 17, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Swantje VöllerDINO study group
Nov 1, 1985·Indian Journal of Pediatrics·R T Bajaj, U V Kolhatkar
Feb 26, 2019·Therapeutic Drug Monitoring·Bhaskar KrishnamurthySourabh Dutta
Apr 14, 2009·Therapeutic Drug Monitoring·Simona PichiniRafael de laTorre
Nov 1, 1987·Drug Intelligence & Clinical Pharmacy·J W GingeryJ A Jernigan
Mar 1, 1986·Indian Journal of Pediatrics·N Buchanan
Dec 1, 1983·Drug Intelligence & Clinical Pharmacy·R Sagraves, J C Bradberry
Oct 14, 2020·Expert Opinion on Drug Metabolism & Toxicology·Matthijs W van HoogdalemTomoyuki Mizuno
Oct 21, 2020·European Journal of Clinical Pharmacology·Janthima Methaneethorn, Nattawut Leelakanok

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Chromatography, Gas-Liquid
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