Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys

American Journal of Veterinary Research
N S MatthewsK L Mealey

Abstract

To describe the pharmacokinetics of phenylbutazone and oxyphenbutazone after IV administration in miniature donkeys. 6 clinically normal miniature donkeys. Blood samples were collected before and 5, 10, 20, 30, 45, 60, 90, 120, 180, 240, 300, 360, and 480 minutes after IV administration of phenylbutazone (4.4 mg/kg of body weight). Serum was analyzed in triplicate by use of high-performance liquid chromatography for determination of phenylbutazone and oxyphenbutazone concentrations. The serum concentration-time curve for each donkey was analyzed separately to estimate model-independent pharmacokinetic variables. Serum concentrations decreased rapidly after IV administration of phenylbutazone, and they reached undetectable concentrations within 4 hours. Values for mean residence time ranged from 0.5 to 3.0 hours (median, 1.1 hour), whereas total body clearance ranged from 4.2 to 7.5 ml/kg/min (mean, 5.8 ml/kg/min). Oxyphenbutazone appeared rapidly in the serum; time to peak concentration ranged from 13 to 41 minutes (mean, 26.4 minutes), and peak concentration in serum ranged from 2.8 to 4.0 mg/ml (mean, 3.5 microg/ml). Clearance of phenylbutazone in miniature donkeys after injection of a single dose (4.4 mg/kg, IV) is rapid. Co...Continue Reading

References

Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·E F JohnsonR H Tukey
Sep 1, 1972·Journal of Applied Physiology·M K YousefD V Freeland
Dec 2, 1998·British Journal of Clinical Pharmacology·S NawaratneD J Morgan

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Citations

Feb 1, 2009·Animal : an International Journal of Animal Bioscience·F A BurdenA F Trawford
Nov 30, 2004·American Journal of Veterinary Research·Katrina L MealeyTex S Taylor
May 11, 2013·Journal of Veterinary Pharmacology and Therapeutics·C D Lee, L K Maxwell
Sep 24, 2015·Veterinary Record Open·F H Regan Nee AshleyH R Whay

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