Pharmacokinetics of reduced iso-α-acids in volunteers following clear bottled beer consumption

Forensic Science International : Synergy
Luke N RoddaOlaf H Drummer

Abstract

Reduced iso-α-acids (reduced IAA) consisting of the rho-, tetrahydro- and hexahydro-IAA groups (RIAA, TIAA and HIAA, respectively) are ingredient congeners specific to beer and generally found in clear and also occasionally green bottled beer. Concentrations of reduced IAA were determined in the blood and urine of five volunteers over 6h following the consumption of small volumes of beer containing each of the reduced IAA. The reduced IAA were absorbed and bioavailable with peak concentrations at 0.5h followed by a drop of generally fivefold by 2h. Preliminary pharmacokinetics of these compounds in humans shows relatively small inter-individual differences and an estimated short half-life varying between ∼38 and 46min for the three groups. Comparison of RIAA analyte ratios within the group indicate that some analytes eliminate relatively faster than others and the formation of metabolite products was observed. Preliminary urine analysis showed only unmodified RIAA analytes were detectable throughout 6h and suggests extensive phase I metabolism of TIAA and HIAA analytes. In authentic forensic casework where clear or green bottled beers are consumed, the identification of reduced IAA groups may provide a novel method to target in...Continue Reading

References

Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C I ChappelM Chagnon
Mar 12, 2003·Medicine, Science, and the Law·R Iffland, A W Jones
Sep 4, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Kevin HuvaereDenis De Keukeleire
Sep 15, 2004·Forensic Science International : Synergy·D Krause, H-D Wehner
Mar 25, 2008·Phytochemistry·Amy J HallMatthew L Tripp
Aug 30, 2008·Journal of Agricultural and Food Chemistry·Takeshi Kunimune, Thomas H Shellhammer
Jul 20, 2010·BMC Pharmacology·Nitish K MishraGajendra Ps Raghava
Oct 16, 2010·Bioinformatics·Patrik RydbergLars Olsen
Sep 7, 2011·Food & Function·Ko CattoorArne Heyerick
Mar 5, 2013·Forensic Science, Medicine, and Pathology·Luke N RoddaOlaf H Drummer
Apr 20, 2014·Forensic Science International : Synergy·Luke N RoddaOlaf H Drummer
Apr 30, 2014·Journal of Analytical Toxicology·Luke N RoddaOlaf H Drummer

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Citations

Oct 27, 2016·Journal of Proteome Research·Gözde GürdenizLars Ove Dragsted
Oct 17, 2014·Forensic Science, Medicine, and Pathology·Luke N RoddaOlaf H Drummer
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria PonticelliLuigi Milella

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