Pharmacokinetics of rifapentine in children

The Pediatric Infectious Disease Journal
Michael J BlakeG L Kearns

Abstract

Rifapentine is a rifamycin antibiotic approved for the treatment of pulmonary infections caused by Mycobacterium tuberculosis. Although the pharmacokinetics of rifapentine has been investigated in adolescents and adults, no studies have assessed the pharmacokinetics of this drug in children or infants. Twenty-four children (7.1 +/- 3.3 years; mean +/- 1 SD, 27.9 +/- 11.9 kg) were enrolled in this open label study. Children received a single oral dose (10 to <30 kg body weight received 150 mg; 30 to <60 kg body weight received 300 mg), followed by repeated blood sampling (n = 11) for 32 hours. Rifapentine and 25-desacetyl rifapentine were quantitated by a validated high-pressure liquid chromatography method. Pharmacokinetic parameters were determined using a model-independent approach. A significant difference in dose-normalized area under the curves (AUC0-n and AUC0-infinity) was observed between children receiving the 150 and 300 mg doses, which was accounted for by differences in age between the dosing arms. In separate analyses, including data from adults, further age-dependence in total body exposure (reflected by AUC) and elimination was observed. Adverse events associated with rifapentine were mild and included gastric di...Continue Reading

References

Mar 1, 1990·The American Review of Respiratory Disease·L B HeifetsM A Flory
Aug 26, 1998·Pharmaceutical Research·A C KeungS J Weir
Oct 17, 1998·Journal of Pharmacokinetics and Biopharmaceutics·A C KeungS J Weir
Oct 26, 1999·The Pediatric Infectious Disease Journal·J D MarshallG L Kearns
Jun 20, 2001·Pediatric Clinics of North America·J S Leeder
Dec 31, 2002·Toxicology·Urs-A Meyer, Josef Gut
Jun 21, 2003·International Journal of Clinical Pharmacology and Therapeutics·M Müller
Sep 19, 2003·The New England Journal of Medicine·Gregory L KearnsRalph E Kauffman
Feb 14, 2004·American Journal of Respiratory and Critical Care Medicine·Marc WeinerUNKNOWN Tuberculosis Trials Consortium
Nov 2, 2004·Pediatric Annals·Lisa V Adams

❮ Previous
Next ❯

Citations

Dec 14, 2011·The New England Journal of Medicine·Timothy R SterlingUNKNOWN TB Trials Consortium PREVENT TB Study Team
Nov 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sonal S MunsiffShama Desai Ahuja
Sep 1, 2013·Journal of the Pediatric Infectious Diseases Society·Andrea T CruzJeffrey R Starke
Jul 24, 2010·The Pediatric Infectious Disease Journal·Lilly M VerhagenPeter W M Hermans
Jul 27, 2011·Antimicrobial Agents and Chemotherapy·S TheeH S Schaaf
Mar 8, 2007·American Journal of Respiratory and Critical Care Medicine·Wing Wai Yew, Chi Chiu Leung
Jun 1, 2014·Journal of the Pediatric Infectious Diseases Society·Marc WeinerUNKNOWN Tuberculosis Trials Consortium PREVENT TB Pharmacokinetic Group
Nov 28, 2015·British Journal of Clinical Pharmacology·Alessandro SchipaniGerry Davies
Oct 19, 2016·PLoS Neglected Tropical Diseases·Aurélie ChauffourVincent Jarlier
Dec 5, 2008·Expert Review of Anti-infective Therapy·Andrea T Cruz, Jeffrey R Starke
Aug 15, 2017·Expert Review of Clinical Pharmacology·Omamah AlfarisiCharles A Peloquin
Apr 4, 2021·International Journal of Molecular Sciences·Sonia Romero-CorderoConstanza Morén
Jan 25, 2018·Pediatrics·Andrea T Cruz, Jeffrey R Starke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.