PMID: 2510280Jan 1, 1989Paper

Pharmacokinetics of rioprostil in rats

Scandinavian Journal of Gastroenterology. Supplement
J K Petersen-von GehrW Steinke

Abstract

The pharmacokinetics of rioprostil in rats has been investigated following a single intravenous or oral dose of rioprostil between 0.004 and 10 mg/kg. Rioprostil is eliminated from plasma following an intravenous dose rapidly (t1/2 = 0.22 h) and nearly exclusively by biotransformation. The high total clearance (CL = 5.4 l.h-1.kg-1) indicates an additional extrahepatic metabolism. A systemic bioavailability of 2%, in spite of a rapid and nearly complete absorption (fa = 90%), indicates an extended first-pass effect. Twenty-four hours after the administration of [3H]rioprostil the residual radioactivity in the animal amounted to less than 1% of the dose administered.

References

Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Jan 1, 1981·Journal of Inherited Metabolic Disease·N G Kennaway, H C Curtis

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·U TüberM Mahler

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