Pharmacokinetics of salicylates in elderly

Gerontology
G CunyF Penin

Abstract

In order to study changes in the pharmacokinetics of salicylates in old people, we used two groups of inpatients without hepatic or renal impairment: the first comprised 15 patients more than 65 years old, mean age 77 years; the second, 7 patients of mean age 21 years. Each patient was given 1 g of acetylsalicylic acid orally in the morning while fasting. Blood samples were subsequently taken after 30, 60 and 90 min and 2, 3, 4, 6, 8, 10, and 24 h. Fluorimetric assay results were analyzed kinetically with a mathematical model corresponding to a single diffusion compartment model. The results showed only a slight increase in the absorption half-time in old subjects, and a marked increase in elimination half-time (3.71 and 2.38 h in old and young subjects, respectively; t = 2.33: p less than 0.05) and in the volume of distribution (5.51 and 3.83 liters respectively; t = 3.20: p less than 0.1). On the other hand, bioavailability varied little, as did metabolic clearance. This study confirms that intestinal absorption of this drug is not much impaired in old people, while hepatic and/or renal elimination functions are changed. This finding agrees with results found for aminopyrine, antipyrine, and digoxin.

Citations

Apr 1, 1991·Journal of Clinical Pharmacology·H Y AbdallahK A Conrad
Jan 1, 1990·European Journal of Clinical Pharmacology·D C DhasmanaG G Mansharamani
Jan 1, 1985·European Journal of Clinical Pharmacology·L J LeskoN R Cutler
Jan 1, 1983·European Journal of Clinical Pharmacology·M S RobertsP M Brooks
Jan 1, 1988·European Journal of Clinical Pharmacology·F A RossiV Maresca
Jan 1, 1988·Pharmacology & Therapeutics·J Roberts, N Tumer
Mar 1, 1989·Archives of Gerontology and Geriatrics·D PlattH Eicher
Dec 1, 1992·Free Radical Biology & Medicine·A GhiselliA Ferro-Luzzi
Jan 1, 1994·Fundamental & Clinical Pharmacology·L Chanalet, P Lapalus
Jan 1, 1987·Critical Reviews in Clinical Laboratory Sciences·T C Kwong
Sep 22, 2009·Clinics in Geriatric Medicine·Khaled Abdel-Kader, Paul M Palevsky
Feb 1, 1997·The American Journal of Medicine·D H Solomon, J H Gurwitz
Dec 1, 1980·Journal of the American Geriatrics Society·E B Nelson, J R Levitt
May 1, 1985·British Journal of Clinical Pharmacology·P C HoV J Heazlewood
Mar 1, 1988·Journal of the American Geriatrics Society·R B Scott, M C Mitchell
Apr 1, 1982·Journal of the American Geriatrics Society·M DivollD J Greenblatt
Feb 1, 1981·Acta Anaesthesiologica Scandinavica·J KantoT Yrjänä
Jun 14, 1983·The American Journal of Medicine·E CotlierM Brescia
Jun 1, 1989·Journal of the American Geriatrics Society·R B Bailey, S R Jones
Jun 1, 1988·Journal of Clinical Pharmacology·B J Cusack
Mar 25, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Christy C Bridges, Rudolfs K Zalups

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