PMID: 15379435Sep 24, 2004Paper

Pharmacokinetics of selamectin in dogs after topical application

Veterinary Research Communications
J DupuyM Alvinerie

Abstract

Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72 +/- 5.13 ng/ml for males and 22.65 +/- 11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration-time curve (AUC) was 192.08 +/- 63.85 ng.day/ml for males and 370.97 +/- 146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.

Citations

Nov 27, 2008·Acta Veterinaria Scandinavica·Maggie A Fisher, David J Shanks
May 2, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Jennifer J D'AgostinoJohn P Hoover
Apr 10, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Alicia HahnButch Kukanich
Jun 15, 2005·Journal of Veterinary Pharmacology and Therapeutics·J GriffinD J Brayden
Mar 21, 2012·Journal of Veterinary Pharmacology and Therapeutics·R BaynesP-L Toutain
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Apr 10, 2020·Journal of Veterinary Pharmacology and Therapeutics·André Tadeu GotardoSilvana Lima Górniak

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