PMID: 8583537Aug 1, 1995Paper

Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after intravenous administration to healthy and pneumonic pigs

Journal of Veterinary Pharmacology and Therapeutics
M J MengelersA S Van Miert

Abstract

The pharmacokinetics of two sulfonamide/trimethoprim combinations were investigated after intravenous administration to clinically healthy pigs and to the same pigs following a challenge with Actinobacillus pleuropneumoniae toxins. Endobronchial challenge with A. pleuropneumoniae toxins resulted in fever, increased white blood cell counts and decreased water and feed consumption. Healthy, as well as febrile, pigs were given sulfadimethoxine (SDM) or sulfamethoxazole (SMX) intravenously at a dose of 25 mg/kg b.w. in combination with 5 mg trimethoprim (TMP) per kg body weight. The pharmacokinetic parameters of the sulfonamides as well as their main metabolites (acetyl sulfonamides) were not significantly different in healthy and febrile pigs. In healthy and pneumonic pigs, the mean elimination half-lives of SDM were 12.9 h and 13.4 h, respectively, those of SMX 2.5 h and 2.7 h, respectively, and those of TMP 2.8 h and 2.6 h, respectively. Distribution volumes in healthy and febrile pigs of SDM and SMX varied between 0.2 and 0.4 L/kg, and those of TMP between 1.1 and 1.6 L/kg. The mean AUC of TMP was decreased and the volume of distribution and total body clearance of TMP were increased in febrile pigs. Protein binding of the drug...Continue Reading

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Citations

Dec 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·D GirouxG P Martineau
Sep 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P E AdamsG D Paulson
Nov 26, 2016·Journal of Veterinary Pharmacology and Therapeutics·J W SparksJ F Coetzee

Related Concepts

Actinobacillus Infections
Antibiotics
Bacterial Toxins
High Pressure Liquid Chromatography Procedure
Water Consumption
Drug Combinations
Ingestion
Half-Life
Intravenous Injections
Total Body Clearance Rate

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