Pharmacokinetics of sulfamethoxazole and trimethoprim in donkeys, mules, and horses

American Journal of Veterinary Research
Kenneth E PeckK L Mealey

Abstract

To compare serum disposition of sulfamethoxazole and trimethoprim after IV administration to donkeys, mules, and horses. 5 donkeys, 5 mules, and 3 horses. Blood samples were collected before (time 0) and 5, 15, 30, and 45 minutes and 1, 1.25, 1.5, 1.75, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 8, 10, and 24 hours after IV administration of sulfamethoxazole (12.5 mg/kg) and trimethoprim (2.5 mg/kg). Serum was analyzed in triplicate with high-performance liquid chromatography for determination of sulfamethoxazole and trimethoprim concentrations. Serum concentration-time curve for each animal was analyzed separately to estimate noncompartmental pharmacokinetic variables. Clearance of trimethoprim and sulfamethoxazole in donkeys was significantly faster than in mules or horses. In donkeys, mean residence time (MRT) of sulfamethoxazole (2.5 hours) was less than half the MRT in mules (6.2 hours); MRT of trimethoprim in donkeys (0.8 hours) was half that in horses (1.5 hours). Volume of distribution at steady state (Vdss) for sulfamethoxazole did not differ, but Vdss of trimethoprim was significantly greater in horses than mules or donkeys. Area under the curve for sulfamethoxazole and trimethoprim was higher in mules than in horses or donkeys. D...Continue Reading

References

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Citations

Nov 30, 2004·American Journal of Veterinary Research·Katrina L MealeyTex S Taylor
Dec 1, 2011·American Journal of Veterinary Research·Cengiz GokbulutVincenzo Veneziano
Oct 1, 2013·The Veterinary Record·J M Senior
Nov 26, 2013·The Veterinary Clinics of North America. Equine Practice·Stephen D White
Jan 24, 2009·Journal of Veterinary Pharmacology and Therapeutics·C KumM Boyacioglu
Oct 31, 2012·Journal of Veterinary Pharmacology and Therapeutics·C GokbulutV Veneziano
Dec 12, 2013·Journal of Veterinary Pharmacology and Therapeutics·M J RumplerR A Sams
Jul 27, 2018·Equine Veterinary Journal·M DuzT D Parkin
Jun 3, 2020·Animals : an Open Access Journal From MDPI·Marilena BazzanoFulvio Laus

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