Pharmacokinetics of superparamagnetic iron-oxide MR contrast agents in the rat

Investigative Radiology
S MajumdarJ C Gore

Abstract

The in vivo pharmacokinetics and the biodistribution of superparamagnetic iron-oxide particles (AMI25, Advanced Magnetics, Cambridge, MA) were investigated in anesthetized rats. Four different dose concentrations, ranging from 49.8 to 408.9 mumol of Fe (or 2.78-22.84 mg Fe) per kilogram, radiolabeled with 6.0 microCi of 59Fe-AMI25 were injected intravenously into 18 rats. The radioactivity cleared from the circulation with a fast component with a half-life of approximately 10 minutes and a slower component with a half-life of 92 minutes. Both half-lives were independent of the injected dose (ID) in the range of 105.4-408.9 mumol (5.89-22.84 mg) Fe/kg. The relative uptake in the liver, spleen, and kidneys was 57%, 2.9%, and 2.0% of the ID, respectively. At a dose of 52.1 mumol (2.91 mg) of Fe/kg, the relative concentration of iron significantly increased in the liver and decreased in the blood. Within the kidney, autoradiography showed that the iron was selectively taken up by the cortex. In the kidney, a concentration of 0.23 mumol (0.013 mg) Fe/g resulted in a 30% reduction in image intensity in a single echo magnetic resonance image obtained using a spin-echo sequence and an echo time of 70 ms.

Citations

Sep 24, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Chih-Lung ChenChien Ho
Jun 27, 2008·Bioconjugate Chemistry·Benjamin R JarrettAngelique Y Louie
Jul 6, 2000·AJR. American Journal of Roentgenology·M R PaleyP R Ros
Apr 17, 2012·Therapeutic Delivery·Dev Kumar ChatterjeeSunil Krishnan
Sep 25, 2004·Journal of Magnetic Resonance Imaging : JMRI·Karen Briley-SaebøAtle Bjørnerud
Oct 16, 2010·NMR in Biomedicine·Ho-Taek SongJoseph A Frank
Feb 3, 2011·Contrast Media & Molecular Imaging·Emilie BledSylvain Miraux
Jan 1, 1994·Magnetic Resonance Imaging·T C WinterC R Thomas
Feb 6, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Maxim A AbakumovVladimir P Chekhonin
Feb 11, 2016·Chemical Society Reviews·Neus FeliuWolfgang J Parak
Sep 1, 1996·Acta Radiologica·T MasuiB Fritz-Zieroth
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·N MorimotoH Saisho
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·O CleméntR C Brasch
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·H TrillaudJ M Franconi
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·C B GrandinJ Pringot
Apr 3, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karen C Briley-SaeboZahi A Fayad
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O HaugerN Grenier
Feb 7, 2021·Materials·Irene Rubia-RodríguezDaniel Ortega
Aug 19, 2003·Molecular Imaging·Eyk A SchellenbergerLee Josephson
May 29, 2021·Chemical Society Reviews·Chang LuJianghong Rao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved