Pharmacokinetics of tecomin in rats after intragastric and intravenous administration

Biomedical Chromatography : BMC
Lina GuoRufeng Wang

Abstract

The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis, was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo, and then the latter was eliminated slowly. In addition, the simulant in vitro gastrointestinal transformation experiments demonstrated that the basic enteral environment and intestinal bacterial flora also contributed to the metabolism of tecomin to veratric acid.

References

Feb 19, 2002·Journal of Ethnopharmacology·Yao Lan LiPaul Pui-Hay But
Mar 11, 2004·Journal of Asian Natural Products Research·Ru-Feng WangJong-Hee Park
Apr 9, 2011·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Xiuwei Yang, Wei Xu
Aug 4, 2015·Chinese Journal of Natural Medicines·Yu-Shuai PengRu-Feng Wang

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