Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children

Clinical Pharmacology and Therapeutics
J LermanA C Keung

Abstract

Dolasetron mesylate is a selective 5-HT3 receptor antagonist under investigation as an antiemetic in children. Published studies indicate that its antiemetic activity results from the active metabolite (MDL 74,156), which is produced within 10 minutes of administration of dolasetron mesylate. The pharmacokinetics of MDL 74,156 and the safety and tolerability of dolasetron mesylate were studied after a single oral or intravenous dose of 1.2 mg.kg-1 dolasetron mesylate to healthy children from 2 to 12 years of age. Oral dolasetron was administered to 12 children 1 to 2 hours before anesthesia. Intravenous dolasteron was administered to 18 children at induction of anesthesia. Serial blood samples were collected for 24 hours after dosing to measure the plasma concentration of MDL 74,156. Indexes of liver and kidney function were determined, and electrocardiograms and adverse events were recorded.

References

May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M G KrisW F Hahne
Oct 1, 1993·Journal of Pharmaceutical and Biomedical Analysis·T A GillespieJ E Coutant

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Citations

Oct 4, 2011·Clinical Interventions in Aging·Paul GlareRoma Tickoo
Dec 20, 2008·Drugs·Paul A GlareJanet R Hardy
Mar 1, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anthony L Kovac

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