PMID: 6407848Jan 1, 1983Paper

Pharmacokinetics of tocainide in patients with renal dysfunction and during haemodialysis

European Journal of Clinical Pharmacology
U WiegersM Runge

Abstract

The disposition of tocainide was studied in 15 patients with renal dysfunction. In 9 with total renal failure, the plasma half-life ranged from 16.6 to 42.7 h and total plasma clearance from 35 to 94 ml/min. The longest half-lives were found in 1 patient with cirrhosis, 3 taking the enzyme inhibitor allopurinol, and 1 on cimetidine. The mean half-life in the remaining patients was 22.3 +/- 4.8 h (+/- SD). During a 4 h haemodialysis, the half-life in the 9 patients decreased to 8.5 +/- 4.6 h, which was calculated to correspond to removal of 25 +/- 14% of the drug from the body. In 6 patients with impaired renal function (creatinine clearance 10-55 ml/min) the tocainide half-life ranged from 13.2 to 22.0 h and total plasma clearance from 72 to 122 ml/min. One patient was taking allopurinol and 1 dihydralazine, and the mean half-life in the others was 19.2 +/- 4.0 h. The apparent volume of distribution was similar to that found previously in healthy subjects. The results suggest that tocainide elimination is predictably reduced in patients with renal disease.

References

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Citations

Jan 1, 1990·European Journal of Clinical Pharmacology·K M McErlaneG Pillai
Jan 1, 1983·European Journal of Clinical Pharmacology·D OltmannsW Endell
Jan 1, 1985·European Journal of Clinical Pharmacology·J BraunU Gessler
Oct 1, 1989·Cardiovascular Drugs and Therapy·V Rodighiero
Nov 1, 1989·Medical Toxicology and Adverse Drug Experience·C P Denaro, N L Benowitz
Oct 26, 2010·The American Journal of Emergency Medicine·Emine AkıncıFigen Coşkun
Jan 15, 1988·The American Journal of Cardiology·R L Woosley, C Funck-Brentano
Dec 22, 1998·The American Journal of Gastroenterology·P K BlusteinL R Sutherland
Sep 15, 1987·The American Journal of Cardiology·C L RaehlA K Patel
Jan 1, 1985·Neuroradiology·P NakstadR Nyberg-Hansen
Sep 1, 1986·Human Toxicology·C Barnfield, A V Kemmenoe
Jul 3, 1986·The New England Journal of Medicine·D M Roden, R L Woosley
Jan 1, 1986·Drug Intelligence & Clinical Pharmacy·E ForrenceC Mullen
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·G R Hasegawa
Apr 1, 1985·Journal of Clinical Pharmacology·M CanalA Baglin

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