Pharmacokinetics of topical hydrocortisone at plasma level after applications once or twice daily in patients with widespread dermatitis

The British Journal of Dermatology
K Aalto-Korte, M Turpeinen

Abstract

Percutaneous absorption of hydrocortisone was measured by determining plasma cortisol during dexamethasone suppression in 26 patients with widespread atopic dermatitis. The first and second days of treatment with applications of 1% hydrocortisone cream twice daily were studied separately in two groups of six patients. Plasma cortisol levels rose after the first two applications, reaching a maximum in 24 h. The levels then began to fall, indicating possible restoration of the skin barrier. In two other groups of seven patients, the second application was made with a cream base alone. Two types of cream base were studied, one with 60% water and the other with 30% water. With the base containing 30% water, a brief increment was seen after 2 h. On the basis of this pharmacokinetic study, treatment of acute dermatitis could be intensified by applying hydrocortisone cream twice a day on the first day, but from the second day onward one application a day seems to be sufficient.

References

Dec 1, 1978·Journal of Pharmaceutical Sciences·M S Roberts, E Harlock
Apr 1, 1991·The British Journal of Dermatology·M Turpeinen
Jun 1, 1993·The British Journal of Dermatology·K Aalto-Korte, M Turpeinen
Jul 1, 1963·Archives of Dermatology·C F VICKERS

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Citations

Jul 22, 2006·Archives of Dermatological Research·Carolina PellandaChristian Surber
Apr 16, 2002·Clinical and Experimental Dermatology·J P HachemD Roseeuw
Jan 20, 1999·The British Journal of Dermatology·B R Lagos, H I Maibach
Aug 10, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·Thomas HultschJonathan Spergel
Jun 25, 2008·American Journal of Clinical Dermatology·Jonathan M Spergel
Jun 28, 2011·International Journal of Dermatology·Laia RubioJosé L Parra
Sep 16, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·M Udompataikul, W Srisatwaja
Dec 31, 2005·Journal of the American Academy of Dermatology·Ulrich R HenggeMichael J Cork
Nov 1, 2007·Current Medical Research and Opinion·M L Levy
Aug 12, 2015·Journal of Evidence-based Complementary & Alternative Medicine·Rasool ChoopaniMitra Mehrabani
Sep 18, 2016·The British Journal of Dermatology·A-S Halling-OvergaardJ P Thyssen

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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