Pharmacokinetics of tramadol in rat plasma and cerebrospinal fluid after intranasal administration

The Journal of Pharmacy and Pharmacology
Yan ZhaoQinghua Chen

Abstract

We have evaluated the potential of intranasal administration of tramadol. The pharmacokinetic behaviour of tramadol in rat plasma and cerebrospinal fluid (CSF) after intranasal administration was determined and compared with those after intravenous and oral administration. Serial plasma and CSF samples were collected for 6 h, and the drug concentrations were assayed by an HPLC-fluorescence method. The plasma absolute bioavailability values of tramadol after intranasal and oral administration were 73.8% and 32.4%, respectively, in conscious rats. The Cmax (maximum concentration) value after the intranasal dose was lower (P<0.05), and the MRT (mean retention time) was longer (P<0.05) than the values obtained after intravenous administration. A pharmacokinetic study of tramadol in plasma and CSF was undertaken in anaesthetized rats. The absolute bioavailability values in plasma and CSF after intranasal administration were 66.7% and 87.3%, respectively. The Cmax values in plasma and CSF after a nasal dose were lower (P<0.05) than after the intravenous dose. The values of Cmax and AUC0-->6 h in plasma and CSF after intranasal administration were higher than after the oral dose. The mean drug-targeting efficiency after intranasal adm...Continue Reading

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Citations

Jan 29, 2016·International Ophthalmology·Ozgun Cuvas ApanDemet Sengul
Jul 14, 2011·The Journal of Pharmacy and Pharmacology·Mahshid ForoozeshHashem Montaseri
Oct 13, 2011·The Journal of Pharmacy and Pharmacology·Shinri TakasugaMine Kinoshita
Aug 30, 2014·Biopharmaceutics & Drug Disposition·Hua ZhangQiang Zhang
Jan 3, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tjerk BuetersJohan Bylund
Apr 23, 2015·The Veterinary Clinics of North America. Exotic Animal Practice·Michelle G Hawkins
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Krutika SawantSneha Patel
Jul 2, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Behjat SheikholeslamiMohammadreza Rouini
Apr 28, 2010·Expert Review of Neurotherapeutics·Mellar P Davis

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