Pharmacokinetics of tulathromycin after subcutaneous injection in North American bison (Bison bison)

Journal of Veterinary Pharmacology and Therapeutics
K BachtoldM Woodbury

Abstract

Tulathromycin is approved for the treatment of respiratory disease in cattle and swine. It is intended for long-acting, single-dose injection therapy (Draxxin), making it particularly desirable for use in bison due to the difficulty in handling and ease of creating stress in these animals. The pharmacokinetic properties of tulathromycin in bison were investigated. Ten wood bison received a single 2.5 mg/kg subcutaneous injection of Draxxin. Serum concentrations were measured by liquid chromatography-mass spectrometry (LC-MS) detection. Tulathromycin demonstrated early maximal serum concentrations, extensive distribution, and slow elimination characteristics. The mean maximum serum concentration (Cmax) was 195 ng/mL at 1.04 h (tmax) postinjection. The mean area under the serum concentration-time curve, extrapolated to infinity (AUC0-inf ), was 9341 ng · h/mL. The mean apparent volume of distribution (Vd /F) and clearance (Cls/F) was 111 L/kg and 0.4 L/h/kg, respectively, and the mean half-life (t1/2) was 214 h (8.9 days). Compared to values for cattle, Cmax and AUC0-inf were lower in bison, while the Vd /F was larger and the t1/2 longer. Tissue distribution and clinical efficacy studies in bison are needed to confirm the purport...Continue Reading

References

Apr 1, 1997·The Pediatric Infectious Disease Journal·C H Nightingale
Apr 15, 2004·Journal of Agricultural and Food Chemistry·Diana GálerMarcus A Nowakowski
Aug 13, 2004·Journal of Veterinary Pharmacology and Therapeutics·H A BenchaouiS J Sunderland
Feb 3, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Eberhard ScheuchWerner Siegmund
May 8, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Neil DyerEvelyn Schamber
Mar 6, 2010·Handbook of Experimental Pharmacology·Pierre-Louis ToutainAlain Bousquet-Mélou
Jul 20, 2010·Research in Veterinary Science·Gabrielle YoungLisa A Tell
Sep 3, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Kyathanahalli S JanardhanBrad M Debey

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Citations

Aug 21, 2019·Journal of the American Veterinary Medical Association·Maaike O ClaphamLisa A Tell

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