PMID: 8967647Aug 1, 1996Paper

Pharmacokinetics of vancomycin in neonates of postconceptional age less than or equal to 32 weeks

Anales españoles de pediatría
G Ginovart GalianaO Altirriba Valls

Abstract

The objective of the present study was to analyze the pharmacokinetic behavior of vancomycin in neonates of postconceptional age < or = 32 weeks (n = 44). The elimination of the antibiotic was influenced by the concomitant treatment with indomethacin and mechanical ventilation. Close monitoring of renal function of the neonate and vancomycin dosage individualization are mandatory when the above factors are present. Vancomycin dosage guidelines have been determined according to serum creatinine of these premature patients.

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