PMID: 7931891Oct 1, 1994Paper

Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia

The Journal of Pediatrics
W R CromW E Evans

Abstract

We studied the pharmacokinetics of vincristine in children with acute lymphocytic leukemia by means of a specific high-performance liquid chromatographic assay with ultraviolet and electrochemical detection and a limited sampling strategy. Our objectives were to characterize the disposition of vincristine in pediatric patients, to determine clinical, demographic, or biochemical variables related to variability in vincristine pharmacokinetic parameters, and to assess the relationship between pharmacokinetic parameters and vincristine neurotoxicity. Plasma samples were collected at 5 and 30 minutes, and 1, 3, and 24 hours after a rapid intravenous injection during 3 minutes. Vincristine-induced neurotoxicity was retrospectively evaluated by chart review. Pharmacokinetic studies were completed for 64 doses in 54 children between 2 months and 18 years of age (median, 4.3 years), including 2-month-old monozygous twin girls. Vincristine clearance, estimated by Bayesian methods, was highly variable, with a mean (SD) clearance of 19.9 (14.9) ml/min per kilogram or 482 (342) ml/min per square meter. Mean clearance for all subjects was faster than in published studies of adults, which may be related in part to the greater specificity of ...Continue Reading

References

Jan 1, 1982·Cancer Chemotherapy and Pharmacology·Z R DesaiR G Shanks
Jan 1, 1981·Cancer Chemotherapy and Pharmacology·V S Sethi, J C Kimball
Jan 1, 1994·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·S R Degraaf

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Citations

Mar 27, 2013·Paediatric Drugs·Shahrad Rod RassekhMichael R Hayden
Mar 19, 2013·International Journal of Pharmaceutics·Kacoli Sen, Mahitosh Mandal
Aug 19, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ping GuoJames M Gallo
Aug 21, 2003·Cancer Treatment Reviews·E J Estlin, G J Veal
May 5, 1999·Critical Reviews in Oncology/hematology·C E GiddingS S de Graaf
Sep 24, 2010·Current Opinion in Pediatrics·Steven W PaughWilliam E Evans
Jun 11, 2011·Journal of Paediatrics and Child Health·Andrew S MooreRoss Pinkerton
May 5, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gareth J VealClinton F Stewart
Feb 15, 2016·Cancer Chemotherapy and Pharmacology·Gareth J VealTanzina Chowdhury
Aug 2, 2011·Critical Reviews in Oncology/hematology·J Carlijn Van GaalWinette T A van der Graaf
Apr 15, 2011·Cancer Treatment Reviews·Hendrik van den BergJos H Beijnen
Jun 18, 2009·Journal of Clinical Pharmacology·Stephanie LäerBernd Meibohm
Jun 10, 2008·British Journal of Haematology·Gudmar LönnerholmSiebold S N de Graaf
Feb 12, 2014·Expert Opinion on Drug Metabolism & Toxicology·Rabih Said, Apostolia Maria Tsimberidou
Apr 19, 2012·Expert Opinion on Drug Metabolism & Toxicology·Janine R HutsonYaron Finkelstein
Sep 1, 2012·Case Reports in Hematology·Dalia A HamdyManal Zaidan
Jul 2, 2016·Pharmacological Reviews·Phatsapong YingchoncharoenDes R Richardson
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K Pritchard-JonesUNKNOWN Wilm's Tumor Working Group
Jan 18, 2006·Journal of Pharmaceutical and Biomedical Analysis·Mark S SchmidtDaryl J Murry
Dec 8, 2004·Critical Reviews in Oncology/hematology·E GroningerS S N de Graaf
Nov 30, 2007·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Lamya Alnaim
Dec 1, 1996·Medical and Pediatric Oncology·H A Reinders-MesselinkW A Kamps
Nov 26, 1999·Medical and Pediatric Oncology·H Reinders-MesselinkW Kamps
Nov 5, 2019·Pediatric Hematology and Oncology·Nassr NamaShahrad Rod Rassekh
Nov 25, 2003·Hematology·William L CarrollJohn C Reed
Sep 10, 2002·Journal of Pediatric Hematology/oncology·Camille Haisley-RoysterDenise M Adams
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·J H DaviesJ W Gregory
Feb 7, 2003·Fundamental & Clinical Pharmacology·Annick Rousseau, Pierre Marquet
Jun 27, 2002·Pediatric Research·Ellis GroningerSiebold de Graaf
Mar 11, 2015·Journal of Pediatric Hematology/oncology·Anne J LombardiJames I Geller

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