Pharmacokinetics, pharmacodynamics and aspects of neurotoxic effects of four inhaled aliphatic chlorohydrocarbon solvents as relevant in man

European Journal of Drug Metabolism and Pharmacokinetics
H Savolainen

Abstract

Intermittent inhalation exposure of adult male rats to dichloromethane, trichloroethylene, 1,1,1-trichloroethane, perchloroethylene or to a combination of trichloroethylene and 1,1,1-trichloroethane for 5 days, for 6 h daily, induced significantly different accumulations of solvent molecules in the body. Adipose tissue served as a storage site for these solvents. The fat-stored molecules were not totally mobilized during the intermissions in exposure. Co-exposure of trichloroethylene and 1,1,1-trichloroethane induced higher accumulations than those induced by exposure to a single solvent in both the body and the brain. This increase in the accumulation of trichloroethylene might be due to competition with 1,1,1-trichloroethane for a binding site in the oxidative enzyme complex. Behavioural and neurochemical effects on trichloroethylene and dichloromethane exposure may be due to the formation of reactive metabolites. Experiments with 1,1,1-trichloroethane singly or in combination with trichloroethylene showed no observable behavioural effects. Perchloroethylene-induced effects were similarly small although, it caused the highest body concentration detected in these experiments. The metabolic activation of solvent molecules appea...Continue Reading

References

Jun 15, 1975·Biochemical Pharmacology·P A Herd, H F Martin
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Apr 1, 1955·British Journal of Industrial Medicine·E GRANDJEANH ROSENMUND

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Citations

Jan 1, 1985·Journal of Toxicology and Environmental Health·R W D'SouzaS Feldman
Dec 17, 2014·Environmental Science and Pollution Research International·Yoichi KawasakiToshiaki Sendo
Oct 1, 1984·Acta Pharmacologica Et Toxicologica·L M PedersenK H Cohr

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