Pharmacokinetics, Short-term Safety and Efficacy of the Approved Once-daily Darunavir/Ritonavir Dosing Regimen in HIV-infected Children

The Pediatric Infectious Disease Journal
Diane E T BastiaansDutch Paediatric HIV Study Group

Abstract

In this multicenter pharmacokinetic study in HIV-infected children (6-12 years of age), we validated the approved once-daily darunavir/ritonavir dosing recommendations. The geometric mean darunavir area under the plasma concentration-time curve was 63.1 h·mg/L, substantially lower than the mean value observed in adults. However, all trough levels were adequate, and short-term virologic outcome was good. These data support the use of the darunavir/ritonavir once-daily dosing recommendations.

References

Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Rob E AarnoutseDavid M Burger
Jun 1, 2014·Expert Opinion on Drug Metabolism & Toxicology·Diane E T BastiaansDavid M Burger
Jun 22, 2014·The Journal of Antimicrobial Chemotherapy·Thomas N KakudaRichard M W Hoetelmans
May 21, 2016·Journal of the Pediatric Infectious Diseases Society·Kajal B LarsonUNKNOWN International Maternal Pediatric and Adolescent AIDS Clinical Trial Protocol P1058A Team

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Citations

Apr 23, 2019·Therapeutic Drug Monitoring·Hylke WaalewijnUNKNOWN Pediatric Antiretroviral Working Group (PAWG)

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