Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLC-MS/MS methods

Biological & Pharmaceutical Bulletin
You-Jin KimYoung Hee Choi

Abstract

Sauchinone, a biologically active lignan found in Saururus chinensis (Saururaceae), exerts various biological activities against jaundice, inflammatory disease, hepatic steatosis, and oxidative injury. Despite its diverse applications, there exists some information about sauchinone's pharmacokinetics but its tissue distribution, metabolism, and tentative metabolites have not been reported yet. Thus we investigated the pharmacokinetics of sauchinone in mice using microsampling and HPLC-MS/MS methods. Sauchinone presented linear pharmacokinetics at intravenous doses 7.5-20 mg/kg and oral doses 20-500 mg/kg. However, the metabolism of sauchinone was saturated and this agent presented nonlinear pharmacokinetics at 50 mg/kg in the intravenous study. At sauchinone 20 mg/kg the F of sauchinone was 7.76% of the oral dose despite that 77.9% of sauchinone was absorbed. This might be due to extensive metabolism of sauchinone in S9 fractions of liver and small intestine. Tentative metabolites of sauchinone by oxidation, dioxidation, methylation, demethylation, dehydrogenation, or bis-glucuronide conjugation were detected in plasma and S9 fractions of liver, intestine, and kidney. The distribution of sauchinone was considerably high (tissue...Continue Reading

References

Jan 1, 1990·Journal of Natural Products·K V Rao, N S Rao
Dec 1, 1983·Journal of Pharmacokinetics and Biopharmaceutics·M G Lee, W L Chiou
Jul 1, 1993·Pharmaceutical Research·B Davies, T Morris
May 10, 2000·Renal Failure·T Yokozawa, Z W Liu
Aug 5, 2000·Journal of Natural Products·S H Sung, Y C Kim
Jul 13, 2002·American Journal of Therapeutics·Charles O EsimoneMicheal U Adikwu
Feb 14, 2006·Current Drug Metabolism·Sonu Sundd Singh
Jul 30, 2009·Biopharmaceutics & Drug Disposition·Young H ChoiMyung G Lee
Sep 23, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Khalid HussainPazillah Ibrahim
Apr 23, 2010·Journal of Natural Products·Adolf Nahrstedt, Veronika Butterweck
Sep 30, 2010·Phytotherapy Research : PTR·Gui-Hua QuanYoung-Won Chin
Jan 10, 2012·Biomedical Chromatography : BMC·Chun-lei XuXiang Li
Sep 11, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Catheleeya MekjaruskulBungorn Sripanidkulchai
Jan 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Long-Hao LiJi-Yan Liu
Jan 30, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young Hee ChoiYoung-Won Chin

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Citations

Oct 14, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Khaled S AbdelkawyFawzy Elbarbry
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eun Chae GongYoung Hee Choi
Feb 10, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Byoung Hoon YouYoung Hee Choi
Jan 27, 2021·Planta medica·Byoung Hoon YouYoung Hee Choi

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