Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents

Journal of Veterinary Science
Wanhe LuoShuyu Xie

Abstract

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance. This review introduces building methods for PK/PD models and describes current PK/PD research progress toward rational dosage regimens for veterinary antimicrobial agents. Finally, the challenges and prospects of PK/PD models in the design of dosage regimens for veterinary antimicrobial agents are reviewed. This review will help to increase awareness of PK/PD modeling among veterinarians and hopefully promote its development and future use.

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Citations

May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magda FerreiraSandra Isabel Aguiar
Jul 3, 2021·Pharmaceutics·Alicia Rodríguez-GascónArantxa Isla

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Software Mentioned

PCNONLIN
NPEM2
SAS
RSTIR
WINNONLIN
PKAnalyst
MKMODEL
STELLA
ADAPT
TOPFIT

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