PMID: 1194444Nov 1, 1975Paper

Pharmacolinetics of fluorocarbon 11 and 12 in dogs and humans

Journal of Clinical Pharmacology
J AdirG M Mergner

Abstract

Blood levels and exhalation bag contents of FC-11 and FC-12 from dogs and humans were used to elucidate the pharmacokinetic model describing the time-course of these agents. The derived pharmacokinetic parameters were in good agreement with the physicochemical properties of these substances. The model was used to estimate the percentage of dose absorbed, which averaged 77 per cent for FC-11 and 55 per cent for FC-12, and to predict the level of FC-11 and FC-12 under a variety of conditions simulating both short- and long-term exposure to the maximum allowable concentrations of these agents. With similar doses, an 8-hour continuous exposure was estimated to produce levels of FC-11 and FC-12 that are much lower than the corresponding levels reported to induce cardiac sensitization in dogs.

References

Oct 1, 1977·American Industrial Hygiene Association Journal·J T Garrett, I Ahmad
Feb 11, 1974·JAMA : the Journal of the American Medical Association·W L Chiou
Apr 5, 1973·The New England Journal of Medicine·R K Bergner, A Bergner
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Feb 1, 1971·Archives of Environmental Health·C F ReinhardtL S Mullin
Mar 1, 1966·American Industrial Hygiene Association Journal·J J Croley

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Citations

Jul 1, 1995·Environmental Science and Pollution Research International·N WinkerH Hofer
Sep 1, 1978·The Journal of School Health·J A Thomas, C F Kegley
Mar 1, 1985·Regulatory Toxicology and Pharmacology : RTP·R P Giovacchini
Nov 27, 2018·Critical Reviews in Toxicology·George M Rusch

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