PMID: 6975765Sep 1, 1981Paper

Pharmacologic and biochemical modulation of human T-lymphocyte colony formation: hormonal influences

Immunopharmacology
D D Eckels, M E Gershwin

Abstract

The generation of T-cell colonies from human peripheral blood lymphocytes is a sensitive in vitro measure of cell-mediated immunity, considered to be under different and/or additional regulatory controls than short-term liquid cultures. The influences of steroids (aldosterone, estradiol, diethylstilbestrol, hydrocortisone, prednisolone, progesterone, testosterone), prostaglandins (PGA1, PGA2, PGB1, PGB2, PGE1, PGE2, PGF1 alpha), bradykinin, cyclic adenosine monophosphate (AMP), cyclic guanosine monophosphate (GMP), epinephrine, glucagon, histamine, insulin, luteinizing hormone, luteotropic hormone, serotonin, and thyroxin on the generation of both T-cell colonies in semisolid phase and induction of transformation in liquid culture was assessed in parallel assays. Steroids uniformly suppressed both types of culture systems, although colony formation appeared more sensitive by several hours of magnitude. In contrast, significant differences in the response of lymphocytes in colony formation assay, compared to liquid transformation, was noted for the other agents. Prostaglandins significantly inhibited colony formation even in the presence of as little as 10(-12) M PGE2; however, liquid culture responses were suppressed only by hi...Continue Reading

References

Apr 1, 1977·Proceedings of the Society for Experimental Biology and Medicine·P PolgarA M Rutenburg
Jan 1, 1978·Immunological Reviews·A C Allison
Jan 1, 1979·Annals of the New York Academy of Sciences·D R WebbI Nowowiejski
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Apr 1, 1980·Arthritis and Rheumatism·M L BernsteinS A Dobson
Jan 1, 1980·Immunological Reviews·K A Smith

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Citations

Oct 1, 1983·Journal of Clinical Immunology·J S Goodwin, J Ceuppens
Oct 15, 1984·The American Journal of Medicine·J S Goodwin
Jun 6, 2008·Trends in Immunology·Rainer H Straub, David S Jessop

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