Pharmacologic and immunologic management of cytomegalovirus infection after solid organ and hematopoietic stem cell transplantation

Expert Review of Clinical Pharmacology
Atibordee Meesing, R R Razonable

Abstract

Cytomegalovirus (CMV) is a common opportunistic infection that causes significant morbidity and preventable mortality after solid-organ and allogeneic hematopoietic stem cell transplantation. Areas covered: Current strategies of pharmacological treatment of CMV in solid-organ and hematologic stem cell transplantation are reviewed. The role of the newly approved drug, letermovir, and other novel investigational compounds is discussed. The complementary role of viral and immunologic monitoring in guiding the optimal role of pharmacologic agents on the management of CMV after transplantation is highlighted. Advances in immunotherapeutics are highlighted. Expert commentary: With advances in therapeutic and diagnostic modalities, the management of CMV infection and disease after transplantation continues to evolve. The authors provide a succinct yet comprehensive review of the current prevention and treatment for CMV infection and disease in transplant recipients. The role of the newly approved drug, letermovir, for CMV prevention is highlighted in the context of current prevention strategies after allogeneic hematopoietic stem cell transplantation. The emerging role of cell-mediated immunologic monitoring, which complements the est...Continue Reading

References

Feb 1, 1993·Annals of Internal Medicine·J M GoodrichJ D Meyers
Aug 1, 1996·Drugs·A P Lea, H M Bryson
Feb 7, 2002·Blood·Pierre ReusserUNKNOWN Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation
Jan 22, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C M IsadaR K Avery
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Carlos PayaUNKNOWN Valganciclovir Solid Organ Transplant Study Group
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Martin R ZamoraDavid Weill
Nov 3, 2005·Nature Reviews. Drug Discovery·Erik De Clercq, Antonín Holý
Jun 2, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Drew J WinstonVoravit Ratanatharathorn
Feb 23, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M BattiwallaB H Segal
Apr 28, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S WalkerR Khanna
May 22, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·N G AlmyroudisG A Papanicolaou
May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kenneth MicklethwaiteDavid Gottlieb
Jul 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A AsbergUNKNOWN VICTOR Study Group
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oscar LenUNKNOWN RESITRA
Feb 12, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Supha K ArthursRaymund R Razonable
Jul 1, 2008·Bone Marrow Transplantation·P LjungmanUNKNOWN European Conference on Infections in Leukemia
Aug 14, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas EfferthManfred Marschall
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Nov 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J EidR R Razonable
Jan 6, 2010·Antimicrobial Agents and Chemotherapy·Peter LischkaHolger Zimmermann
Apr 1, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarP Peeters
Apr 30, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sheri Lewis BateMichael J Cannon
Jun 22, 2010·Reviews in Medical Virology·Michael J CannonTerri B Hyde
Jul 20, 2010·Immunotherapy·Raymund R Razonable
Jul 21, 2010·Expert Opinion on Pharmacotherapy·Raymund R Razonable
Aug 5, 2010·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R K AveryS Villano
Oct 12, 2010·Current Opinion in Organ Transplantation·Tan S MuiGötz U Grigoleit
Apr 28, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D R KaulH Rubsamen-Schaeff

❮ Previous
Next ❯

Citations

Mar 13, 2019·Clinical & Experimental Ophthalmology·Xia Ni WuOren Tomkins-Netzer
Jun 22, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Patricia Suàrez-FernándezRocío Laguna-Goya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.